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LHX2 Antibody

  • 货号：
    CSB-PA012920LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in: Rat kidney tissue
      All lanes: LHX2 antibody at 5.43μg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 45 kDa
      Observed band size: 45 kDa
    • Immunofluorescence staining of Hela cells with CSB-PA012920LA01HU at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) LHX2 Polyclonal antibody
  • Uniprot No.：
    P50458
  • 基因名：
    LHX2
  • 别名：
    hLhx2 antibody; Homeobox protein LH-2 antibody; Homeobox protein LH2 antibody; LH2 antibody; LHX2 antibody; LHX2_HUMAN antibody; LIM homeobox 2 antibody; LIM homeobox protein 2 antibody; LIM HOX gene 2 antibody; LIM/homeobox protein Lhx2 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Rat
  • 免疫原：
    Recombinant Human LIM/homeobox protein Lhx2 protein (197-377AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，LHX2 Antibody (CSB-PA012920LA01HU)，的标记方式是Non-conjugated。对于LHX2 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA012920LB01HU LHX2 Antibody, HRP conjugated ELISA
    FITC CSB-PA012920LC01HU LHX2 Antibody, FITC conjugated
    Biotin CSB-PA012920LD01HU LHX2 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IF
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Acts as a transcriptional activator. Stimulates the promoter of the alpha-glycoprotein gene. Transcriptional regulatory protein involved in the control of cell differentiation in developing lymphoid and neural cell types.
  • 基因功能参考文献：
    1. These data indicate that Lhx2 is capable of blocking proliferation of T-ALL-derived cells by both LMO2-dependent and -independent means. We propose Lhx2 as a new molecular tool for anti-T-ALL drug development. PMID: 29278703
    2. Findings demonstrate that miR-1238 inhibit the proliferation of NSCLC cells at least partly via repression of LHX2, shedding light on the mechanistic interaction of miR-1238 and LHX2 in NSCLC carcinogenesis. PMID: 26189214
    3. Results show that LHX2 is overexpressed in pancreatic ductal adenocarcinoma cells and is involved in promoting cancer cell proliferation and enhanced tumor development. PMID: 25324171
    4. Lhx2 directly regulates tanycyte specification and differentiation in the hypothalamus. PMID: 25505333
    5. This study demonistrated that LHx2 regulates the development of the forebrain hem system. PMID: 23307637
    6. The data indicate a dual role of Lhx2 during EMT and tumor progression: by inducing the expression of PDGF-B, Lhx2 provokes an autocrine PDGF-B/PDGFRbeta loop required for cell migration, invasion and metastatic dissemination PMID: 24423492
    7. The findings indicate that LHX2 regulates the transcription of downstream intrinsic and extrinsic molecules that are essential for early neural differentiation. PMID: 23804753
    8. These results suggest that if LHX2 is involved in pituitary hormone deficiency associated with posterior pituitary and ocular defects, it would be a rare cause of this disease condition. PMID: 22535646
    9. Mutations in LHX2 do not represent a frequent cause of micro/anophthalmia. PMID: 21203406

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  • 亚细胞定位：
    Nucleus.
  • 数据库链接：

    HGNC: 6594

    OMIM: 603759

    KEGG: hsa:9355

    STRING: 9606.ENSP00000362717

    UniGene: Hs.696425