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LIN7A Antibody

  • 货号：
    CSB-PA012963LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: LIN7A antibody at 6µg/ml
      Lane 1: Human placenta tissue
      Lane 2: Mouse kidney tissue
      Lane 3: Mouse liver tissue
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 26 kDa
      Observed band size: 26 kDa
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) LIN7A Polyclonal antibody
  • Uniprot No.：
    O14910
  • 基因名：
    LIN7A
  • 别名：
    hLin-7 antibody; Lin 7 homolog A (C. elegans) antibody; LIN 7A antibody; Lin-7A antibody; LIN7 antibody; LIN7A antibody; LIN7A_HUMAN antibody; MALS-1 antibody; Mammalian LIN 7 1 antibody; Mammalian lin-seven protein 1 antibody; Protein lin-7 homolog A antibody; Tax interaction protein 33 antibody; TIP-33 antibody; Veli-1 antibody; VELI1 antibody; Vertebrate lin-7 homolog 1 antibody; Vertebrate LIN7 homolog 1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Mouse
  • 免疫原：
    Recombinant Human Protein lin-7 homolog A protein (1-233AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，LIN7A Antibody (CSB-PA012963LA01HU)，的标记方式是Non-conjugated。对于LIN7A Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA012963LB01HU LIN7A Antibody, HRP conjugated ELISA
    FITC CSB-PA012963LC01HU LIN7A Antibody, FITC conjugated
    Biotin CSB-PA012963LD01HU LIN7A Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:1000-1:5000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 associates with the motor protein KIF17 to transport vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit NR2B along microtubules. This complex may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells.
  • 基因功能参考文献：
    1. Overexpression of LIN7 or IRSp53 did not prevent the formation of hyperfused mitochondria in cells coexpressing the Drp1 K38A mutant, thus suggesting that LIN7-IRSp53 complex requires functional Drp1 to regulate mitochondrial morphology. PMID: 27320196
    2. This study therefore shows that LIN7A has a crucial role in the polarity abnormalities associated with breast carcinogenesis. PMID: 26887652
    3. LIN7A depletion disrupts cerebral cortex development, contributing to intellectual disability in 12q21-deletion syndrome. PMID: 24658322
    4. LIN7A is a PDZ protein that interacts with human papillomavirus-16 E6 and forms a tripartite complex with MPP7 and DLG1, regulating the stability and localization of DLG1 to cell junctions. PMID: 17237226
    5. Allelic and haplotype association was found between both BDNF and adult ADHD, and LIN-7 and adult ADHD. PMID: 18286632

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  • 亚细胞定位：
    Cell membrane; Peripheral membrane protein. Basolateral cell membrane; Peripheral membrane protein. Cell junction. Cell junction, synapse, postsynaptic density membrane; Peripheral membrane protein. Cell junction, tight junction.
  • 蛋白家族：
    Lin-7 family
  • 组织特异性：
    Expressed in brain, testis, kidney, placenta and liver.
  • 数据库链接：

    HGNC: 17787

    OMIM: 603380

    KEGG: hsa:8825

    STRING: 9606.ENSP00000447488

    UniGene: Hs.144333