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  4. LIN7C Antibody

LIN7C Antibody

  • 货号：
    CSB-PA012965GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q9NUP9
  • 基因名：
    LIN7C
  • 别名：
    hLin 7 antibody; hLin7 antibody; LIN 7 antibody; Lin 7 homolog A antibody; LIN 7A antibody; LIN 7B antibody; LIN 7C antibody; Lin-7C antibody; Lin7 homolog A antibody; LIN7A antibody; LIN7C antibody; LIN7C_HUMAN antibody; MALS 1 antibody; MALS antibody; MALS-3 antibody; MALS1 antibody; Mammalian LIN 7 1 antibody; Mammalian lin seven protein 1 antibody; Mammalian lin-seven protein 3 antibody; Mammalian LIN7 1 antibody; MGC148143 antibody; Protein lin 7 homolog B antibody; Protein lin 7 homolog C antibody; Protein lin-7 homolog C antibody; protein lin7 homolog A antibody; Tax interaction protein 33 antibody; TIP 33 antibody; TIP33 antibody; VELI 1 antibody; Veli 1 protein antibody; Veli-3 antibody; VELI1 antibody; Velis antibody; Vertebrate LIN 7 homolog 1 antibody; Vertebrate lin-7 homolog 3 antibody; Vertebrate LIN7 homolog 1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human LIN7C
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 associates with the motor protein KIF17 to transport vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit NR2B along microtubules. This complex may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells.
  • 基因功能参考文献：
    1. Data show that mirtazapine caused substantial up-regulation of the Lin-7C/beta-catenin pathway in a metastatic squamous cell carcinomas (hSCCs) cell line and melanoma-derived cell line. PMID: 24961284
    2. The Dlg1-MPP7-Mals3 heterotrimer consists of 2 pairs of heterodimeric L27 domains. These 2 dimers are asymmetric due to the large difference between the N- and C-terminal tandem L27 domain of MPP7. PMID: 20702775
    3. analysis of the solution structure of the heterodimer composed of the L27 domains from LIN-2 and LIN-7 PMID: 16147993
    4. LIN7C is a PDZ protein that interacts with human papillomavirus-16 E6 and forms a tripartite complex with MPP7 and DLG1, regulating the stability and localization of DLG1 to cell junctions. PMID: 17237226
    5. Overexpression of the Lin-7C gene in an OSCC cell clone does not contribute to underproliferation but results in a noninvasive phenotype with elevated beta-catenin expression. PMID: 17942893
    6. Allelic and haplotype association was found between both BDNF and adult ADHD, and LIN-7 and adult ADHD. PMID: 18286632

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  • 亚细胞定位：
    Cell membrane; Peripheral membrane protein. Basolateral cell membrane; Peripheral membrane protein. Cell junction. Cell junction, synapse, postsynaptic density membrane; Peripheral membrane protein. Cell junction, tight junction.
  • 蛋白家族：
    Lin-7 family
  • 数据库链接：

    HGNC: 17789

    OMIM: 612332

    KEGG: hsa:55327

    STRING: 9606.ENSP00000278193

    UniGene: Hs.91393