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LLGL1 Antibody

  • 货号：
    CSB-PA831655
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA831655(LLGL1 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using CSB-PA831655(LLGL1 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • 其他：

产品详情

  • Uniprot No.：
    Q15334
  • 基因名：
  • 别名：
    DLG4 antibody; DLG4, formerly antibody; Hugl 1 antibody; HUGL antibody; Hugl-1 antibody; HUGL1 antibody; Human homolog to the D-lgl gene protein antibody; L2GL1_HUMAN antibody; Lethal giant larvae homolog 1 (Drosophila) antibody; Lethal giant larvae homolog 1 antibody; Lethal(2) giant larvae protein homolog 1 antibody; LLGL antibody; Llgl1 antibody; Ly 49G2 antibody; Ly49G2 antibody; Mgl1 antibody; Mlgl antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthetic peptide of Human LLGL1
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    IHC 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Cortical cytoskeleton protein found in a complex involved in maintaining cell polarity and epithelial integrity. Involved in the regulation of mitotic spindle orientation, proliferation, differentiation and tissue organization of neuroepithelial cells. Involved in axonogenesis through RAB10 activation thereby regulating vesicular membrane trafficking toward the axonal plasma membrane.
  • 基因功能参考文献：
    1. loss of Llgl1 results in EGFR mislocalization, promoting pre-neoplastic changes PMID: 27542214
    2. these results revealed that miR-652-3p execute a tumor-promoter function in non-small cell lung cancer through direct binding and regulating the expression of Lgl1 PMID: 26934648
    3. Older age is a strong predictor of CNS involvement in patients seropositive for CASPR2-IgG or LGI1-IgG. Pain, peripheral manifestations, and stereotypic paroxysmal dizziness spells are common with LGI1-IgG. PMID: 28628235
    4. Reduced expression of Hugl 1 predicts poor survival in lung SqCC patients. The expression of Hugl 1 was inversely correlated with both overall survival rate and tumor stage. PMID: 26662669
    5. Our results support the growing appreciation that the tumour regulatory functions of Scribble, and other polarity protein family members, are context dependent. PMID: 25982280
    6. this study provides the evidence that Hugl-1 inhibits glioma cell growth in intracranial model of nude mice, suggesting that Hugl-1 might be a potential tumor target for glioma therapy. PMID: 26341367
    7. Lgl1 has a role in inhibiting glioblastoma PMID: 25426552
    8. PTEN loss leads to the phosphorylation and inactivation of Lgl by atypical protein kinase C in glioblastoma cells. PMID: 23907540
    9. Suggest that Hugl-1 induces growth suppression and apoptosis in a human esophageal squamous cell carcinoma cell line both in vitro and in vivo. PMID: 23864775
    10. inactivation of Llgl1 enhances hematopoietic stem cells self-renewal and fitness and is associated with unfavorable outcome in human acute myeloid leukemia PMID: 23277453
    11. Preservation of HUGL-1 expression in pancreatic adenocarcinoma is a good prognostic factor that contributes to a better overall survival PMID: 22843887
    12. Hugl-1 can act as a tumour suppressor in Drosophila and thus is the functional homologue of lgl PMID: 15467749
    13. downregulation of Hugl-1 contributes to colorectal cancer progression PMID: 15735678
    14. loss of Hugl-1 expression contributes to melanoma progression PMID: 16170365
    15. aPKCzeta cortical loading is associated with Lgl cytoplasmic release and tumor growth in Drosophila and human epithelia PMID: 17369850
    16. loss of Hugl-1 expression in endometrial cancer may contribute to lymph node metastasis and it can be a factor of poor prognosis. PMID: 18074678
    17. Results provide the first evidence that Hugl-1 mRNA is frequently mutated by aberrant splicing exclusively in HCC, which may be involved in HCC progression. PMID: 19447873

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  • 亚细胞定位：
    Early endosome membrane. Golgi apparatus, trans-Golgi network membrane. Golgi apparatus membrane. Cell projection, axon. Cytoplasm, cytoskeleton.
  • 蛋白家族：
    WD repeat L(2)GL family
  • 组织特异性：
    Expressed in brain, kidney, and muscle but is barely seen in heart and placenta. Down-regulated or lost in all cell lines and in most of the tumor samples analyzed. Loss was associated with advanced stage of the disease.
  • 数据库链接：

    HGNC: 6628

    OMIM: 600966

    KEGG: hsa:3996

    STRING: 9606.ENSP00000321537

    UniGene: Hs.513983