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LLGL2 Antibody

  • 货号：
    CSB-PA889962
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA889962(LLGL2 Antibody) at dilution 1/35, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • 其他：

产品详情

  • Uniprot No.：
    Q6P1M3
  • 基因名：
  • 别名：
    HGL antibody; Human giant larvae homolog antibody; L2GL2 antibody; L2GL2_HUMAN antibody; Lethal 2 giant larvae protein homolog 2 antibody; Lethal giant larvae homolog 2 antibody; Lethal(2) giant larvae protein homolog 2 antibody; LGL2 antibody; LLGL2 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Synthetic peptide of Human LLGL2
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    IHC 1:25-1:100
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Part of a complex with GPSM2/LGN, PRKCI/aPKC and PARD6B/Par-6, which may ensure the correct organization and orientation of bipolar spindles for normal cell division. This complex plays roles in the initial phase of the establishment of epithelial cell polarity.
  • 基因功能参考文献：
    1. The crystal structures of the Dlg4 GK domain in complex with two phosphor-Lgl2 peptides reveal the molecular mechanism underlying the specific and phosphorylation-dependent Dlg/Lgl complex formation. PMID: 24513855
    2. It is correlated with lymphatic invasion and lymph node metastasis. PMID: 24318287
    3. Loss or aberrant Lgl2 staining was useful in identifying Barrett gastric foveolar dysplasia PMID: 23332925
    4. Hugl-2 induces MET and suppresses Snail tumorigenesis. PMID: 22580609
    5. Hugl1 and Hugl2 play an essential role in the maintenance of breast epithelial polarity and differentiated cell morphology, as well as growth control. PMID: 23110097
    6. There is a role of Lgl2 immunohistochemistry as an adjunct in the diagnosis of foveolar-type gastric dysplasia. PMID: 20941506
    7. Lgl2 differentiates pancreatic intraepithelial neoplasia-3 and ductal adenocarcinoma of the pancreas from lower-grade pancreatic intraepithelial neoplasias. PMID: 20233622
    8. binding between Lgl2 and LGN play a role in mitotic spindle organization through regulating formation of the LGN.NuMA complex; Lgl2 forms a Lgl2.Par-6.aPKC.LGN complex, which responds to mitotic signaling to establish normal cell division PMID: 15632202
    9. The identification and functional characterization of the promoter region ( approximately 1.2kb) of the Hugl-2 gene are reported. PMID: 18155665
    10. Retention of Lgl2 expression is critical for the epithelial phenotype;its loss might be involved in metastasis. PMID: 18199550
    11. We propose that Lgl2 may be a potential marker to rule out gastric epithelial dysplasia and adenocarcinoma in diagnostic specimens. PMID: 19407852

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  • 亚细胞定位：
    Cytoplasm. Note=Localized in the perinuclear structure and faintly at the cell-cell contacts sites in the interphase. Localized at the cell periphery during metaphase. Cortical localization in mitotic cells. Found in the lateral region of polarized epithelial cells.
  • 蛋白家族：
    WD repeat L(2)GL family
  • 数据库链接：

    HGNC: 6629

    KEGG: hsa:3993

    STRING: 9606.ENSP00000376333

    UniGene: Hs.514477