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LMO1 Antibody

  • 货号：
    CSB-PA02055A0Rb
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: LMO1 antibody at 2µg/ml
      Lane 1: EC109 whole cell lysate
      Lane 2: 293T whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/15000 dilution
      Predicted band size: 18 kDa
      Observed band size: 50 kDa
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) LMO1 Polyclonal antibody
  • Uniprot No.：
    P25800
  • 基因名：
    LMO1
  • 别名：
    Cysteine rich protein TTG 1 antibody; Cysteine rich protein TTG1 antibody; Cysteine-rich protein TTG-1 antibody; LIM domain only 1 antibody; LIM domain only protein 1 antibody; LMO 1 antibody; LMO-1 antibody; lmo1 antibody; MGC116692 antibody; RBTN 1 antibody; RBTN1 antibody; RBTN1_HUMAN antibody; RHOM 1 antibody; RHOM1 antibody; Rhombotin 1 antibody; Rhombotin-1 antibody; Rhombotin1 antibody; T cell translocation protein 1 antibody; T-cell translocation protein 1 antibody; TTG 1 antibody; TTG1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Rhombotin-1 protein (5-156AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，LMO1 Antibody (CSB-PA02055A0Rb)，的标记方式是Non-conjugated。对于LMO1 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA02055B0Rb LMO1 Antibody, HRP conjugated ELISA
    FITC CSB-PA02055C0Rb LMO1 Antibody, FITC conjugated
    Biotin CSB-PA02055D0Rb LMO1 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:1000-1:5000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    May be involved in gene regulation within neural lineage cells potentially by direct DNA binding or by binding to other transcription factors.
  • 基因功能参考文献：
    1. Target genes of the LMO1-regulated microRNAs and their relevant pathways may be a potential therapeutic targe PMID: 30194082
    2. IKZF1 rs10235796 C allele, IKZF1 rs6964969A>G, CDKN2A rs3731246 G>C, and CDKN2A rs3731246 C allele were signi fi cantly associated with Acute Lymphoblastic Leukemia in Yemenis of Arab-Asian descent. Borderline association found in IKZF1 rs4132601 T>G variant. No associations found with LMO1 rs442264; rs3794012; rs4237770 PMID: 28768142
    3. These results suggested that LMO1 gene rs110419 A > G polymorphism may contribute to protection against neuroblastoma PMID: 27009839
    4. A C-to-T single nucleotide transition occurs as a somatic mutation in noncoding sequences 4 kb upstream of the transcriptional start site of the LMO1 oncogene in primary samples from patients with T-cell acute lymphoblastic leukaemia. This conforms to an APOBEC-like cytidine deaminase mutational signature and a new MYB binding site driving high levels of LMO1 expression. PMID: 28260788
    5. LMO1 is an important oncogene that promotes neuroblastoma initiation, progression, and widespread metastatic dissemination. PMID: 28867147
    6. LMO1 appears to be a coactivator of AR involved in the progression of prostate cancer PMID: 26459575
    7. data suggest that genetic variants in LMO1 are associated with increased NB risk in Chinese children. PMID: 26030754
    8. a polymorphism within a super-enhancer element in the first intron of LMO1 influences neuroblastoma susceptibility through differential GATA transcription factor binding and direct modulation of LMO1 expression in cis PMID: 26560027
    9. LMO1 is a commonly activated tumor promoter that activates AKT signaling in non-small cell lung cancer. PMID: 25037573
    10. LMO1 is a commonly activated tumor promoter that activates AKT signaling in colorectal cancer and a new predictive marker for targeted therapy. PMID: 24845030
    11. results show that LMO1 is poised for expression in normal progenitors, where activation of SCL/TAL1 together with a breakdown of epigenetic repression of LMO1 regulatory elements PMID: 23302769
    12. genetic variants within LMO1 are associated with acute lymphoblastic leukemia and identify this gene as a strong candidate for precursor B-cell leukemogenesis. PMID: 21602560
    13. data show that common polymorphisms at the LMO1 locus are strongly associated with susceptibility to developing neuroblastoma, but also may influence the likelihood of further somatic alterations at this locus, leading to malignant progression PMID: 21124317
    14. 60% of transgenic mice that overexpressed both OLIG2 and LMO1 developed pre-T lymphoblastic lymphoma/leukemia with large thymic tumor masses. PMID: 16103065
    15. The present data suggest that TGF-beta, LMO1, possibly RUNX3, and GSDM form a regulatory pathway for directing the pit cells to apoptosis. PMID: 17471240

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  • 相关疾病：
    A chromosomal aberration involving LMO1 may be a cause of a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(11,14)(p15;q11) with TCRD.
  • 亚细胞定位：
    Nucleus.
  • 组织特异性：
    Expressed mainly in the central nervous. Low level of expression in other tissues including thymus.
  • 数据库链接：

    HGNC: 6641

    OMIM: 186921

    KEGG: hsa:4004

    STRING: 9606.ENSP00000338207

    UniGene: Hs.654426