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LMOD1 Antibody

  • 货号：
    CSB-PA013013ESR1HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human ovarian cancer using CSB-PA013013ESR1HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human glioma using CSB-PA013013ESR1HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) LMOD1 Polyclonal antibody
  • Uniprot No.：
    P29536
  • 基因名：
    LMOD1
  • 别名：
    1D antibody; 64 kDa autoantigen 1D antibody; 64 kDa autoantigen 1D3 antibody; 64 kDa autoantigen D1 antibody; 9530015K06Rik antibody; D1 antibody; Leiomodin antibody; Leiomodin-1 antibody; Lmod1 antibody; LMOD1_HUMAN antibody; muscle form antibody; SM LMOD antibody; SM-Lmod antibody; SMLMOD antibody; Smooth muscle leiomodin antibody; Thyroid associated ophthalmopathy autoantigen antibody; Thyroid-associated ophthalmopathy autoantigen antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Leiomodin-1 protein (29-187AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Mediates nucleation of actin filaments.
  • 基因功能参考文献：
    1. Loss of LMOD1 results in a reduction of filamentous actin, elongated cytoskeletal dense bodies, and impaired intestinal smooth muscle contractility. PMID: 28292896
    2. Key role for miR-214 in modulation of MEF2C-MYOCD-LMOD1 signaling. PMID: 27144530
    3. Lmod1 is a new SMC-restricted SRF/MYOCD target gene. PMID: 22157009
    4. Lmod1 is a component of the smooth muscle contractile apparatus extractable by high salt, not a transmembrane protein as previously predicted. PMID: 11350761
    5. Lmod1, formerly the 64kD human autoantigen D1, is expressed in smooth muscle and striated extraocular slow muscle fibers, colocalized with myosin in the contractile apparatus. Protein levels are unaltered by hyperthyroidism. PMID: 10520227
    6. Lmod1 is a member of the Tropomodulin family of actin binding proteins, and is most highly expressed in smooth muscle. PMID: 11318603

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  • 亚细胞定位：
    Cytoplasm, myofibril, sarcomere. Cytoplasm, cytoskeleton.
  • 蛋白家族：
    Tropomodulin family
  • 组织特异性：
    Detected in lung vascular smooth muscle (at protein level). Detected in thyroid and extraocular smooth muscle, but not skeletal muscle. Detected in heart, aorta, skeletal muscle, colon, urinary bladder, uterus, stomach, and small intestine.
  • 数据库链接：

    HGNC: 6647

    OMIM: 602715

    KEGG: hsa:25802

    STRING: 9606.ENSP00000356257

    UniGene: Hs.519075