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LPCAT2 Antibody

  • 货号：
    CSB-PA013053LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in: 293 whole cell lysate
      All lanes: LPCAT2 antibody at 5μg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 61, 31 kDa
      Observed band size: 61 kDa
    • IHC image of CSB-PA013053LA01HU diluted at 1:200 and staining in paraffin-embedded human thyroid tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
    • IHC image of CSB-PA013053LA01HU diluted at 1:200 and staining in paraffin-embedded human colon cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) LPCAT2 Polyclonal antibody
  • Uniprot No.：
    Q7L5N7
  • 基因名：
    LPCAT2
  • 别名：
    1 acylglycerophosphocholine O acyltransferase antibody; 1 alkylglycerophosphocholine O acetyltransferase antibody; 1-acylglycerophosphocholine O-acyltransferase antibody; 1-alkylglycerophosphocholine O-acetyltransferase antibody; A330042H22 antibody; Acetyl CoA:lyso PAF acetyltransferase antibody; Acetyl-CoA:lyso-PAF acetyltransferase antibody; Acetyl-CoA:lyso-platelet-activating factor acetyltransferase antibody; acyl CoA:lysophosphatidylcholine acyltransferase 2 antibody; Acyl-CoA:lysophosphatidylcholine acyltransferase member 1 antibody; Acyltransferase like 1 antibody; Acyltransferase like 1A antibody; Acyltransferase-like 1 antibody; AYTL1 antibody; Aytl1a antibody; DKFZp686H22112 antibody; FLJ20481 antibody; lpafat1 antibody; LPC acyltransferase 2 antibody; LPCAT-2 antibody; LPCAT2 antibody; Lyso PAF acetyltransferase antibody; Lyso platelet activating factor (PAF) acetyltransferase antibody; Lyso-PAF acetyltransferase antibody; LysoPAFAT antibody; LysoPAFAT/LPCAT2 antibody; LysoPC acyltransferase 2 antibody; Lysophosphatidylcholine acyltransferase 2 antibody; OTTMUSP00000029641 antibody; PCAT2_HUMAN antibody; RGD1563994 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Lysophosphatidylcholine acyltransferase 2 protein (442-544AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，LPCAT2 Antibody (CSB-PA013053LA01HU)，的标记方式是Non-conjugated。对于LPCAT2 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA013053LB01HU LPCAT2 Antibody, HRP conjugated ELISA
    FITC CSB-PA013053LC01HU LPCAT2 Antibody, FITC conjugated
    Biotin CSB-PA013053LD01HU LPCAT2 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Exhibits both acyltransferase and acetyltransferase activities. Catalyzes the conversion of lysophosphatidylcholine (1-acyl-sn-glycero-3-phosphocholine or LPC) into phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine or PC). Catalyzes the conversion 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone. Involved in platelet-activating factor (PAF) biosynthesis by catalyzing the conversion of the PAF precursor, 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF) into 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (PAF). Also converts lyso-PAF to 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine (PC), a major component of cell membranes and a PAF precursor. Under resting conditions, acyltransferase activity is preferred. Upon acute inflammatory stimulus, acetyltransferase activity is enhanced and PAF synthesis increases. Involved in the regulation of lipid droplet number and size.
  • 基因功能参考文献：
    1. three of these five genes (CXCL14, ITGAX, and LPCAT2) harbored polymorphisms associated with aggressive disease development in a human GWAS cohort consisting of 1,172 prostate cancer patients. PMID: 25411967
    2. Data indicate a strong negative correlation between ALOX15, FADS2, and IL5RA expression with 2-arachidonoylglycerophosphocholine levels in dual asthmatic responses. PMID: 23844124
    3. LPCAT1 and -2 have, in addition to their known function in specialized cells, a ubiquitous role in LD-associated lipid metabolism PMID: 21498505
    4. Our enzymatic assays strongly suggest that the cDNA previously identified as LPCAT2/lyso platelet-activating factor-acetyltransferase cDNA has AGPAT activity and thus we prefer to identify this clone as AGPAT11 as well. PMID: 20363836
    5. The enzyme acetyl-CoA:LYSO-PAF acetyltransferase catalyzes not only biosynthesis of PAF upon acute inflammatory stimulation but also incorporation of arachidonoyl-CoA to produce PAF precursor membrane glycerophospholipids for membrane biogenesis. PMID: 17182612

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  • 亚细胞定位：
    Endoplasmic reticulum membrane; Single-pass type II membrane protein. Golgi apparatus membrane; Single-pass type II membrane protein. Cell membrane; Single-pass type II membrane protein. Lipid droplet.
  • 蛋白家族：
    1-acyl-sn-glycerol-3-phosphate acyltransferase family
  • 数据库链接：

    HGNC: 26032

    OMIM: 612040

    KEGG: hsa:54947

    STRING: 9606.ENSP00000262134

    UniGene: Hs.460857