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LPP Antibody

  • 货号：
    CSB-PA994603
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using CSB-PA994603(LPP Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA994603(LPP Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • 其他：

产品详情

  • Uniprot No.：
    Q93052
  • 基因名：
    LPP
  • 别名：
    DKFZp779O0231 antibody; FLJ30652 antibody; FLJ41512 antibody; LIM domain containing preferred translocation partner in lipoma antibody; LIM domain-containing preferred translocation partner in lipoma antibody; LIM protein antibody; Lipoma preferred partner antibody; Lipoma-preferred partner antibody; lpp antibody; LPP_HUMAN antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthetic peptide of Human LPP
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    IHC 1:25-1:100
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    May play a structural role at sites of cell adhesion in maintaining cell shape and motility. In addition to these structural functions, it may also be implicated in signaling events and activation of gene transcription. May be involved in signal transduction from cell adhesion sites to the nucleus allowing successful integration of signals arising from soluble factors and cell-cell adhesion sites. Also suggested to serve as a scaffold protein upon which distinct protein complexes are assembled in the cytoplasm and in the nucleus.
  • 基因功能参考文献：
    1. Data indicate a function for lipoma preferred partner (LPP) in the formation of invadopodia and a requirement for LPP in mediating the metastatic ability of breast cancer cells. PMID: 28436416
    2. This is the first report of epigenetic regulation of the intronic miR-28-5p expression by promoter DNA methylation of its host gene, LPP. PMID: 28775176
    3. meta-analysis provides robust estimates that polymorphisms in LPP and TAGAP genes are potential risk factors for celiac disease in Europeans and Americans PMID: 28208589
    4. this study shows the importance of PP2A complexes with the LIM domains of lipoma-preferred partner in cell adhesion and migration dynamics PMID: 26945059
    5. alteration of LPP expression markedly changes the collectiveness and metastatic potential of cancer cells PMID: 26028032
    6. Results suggest that rs4686484 is the functional variant in this locus, while LPP expression is decreased in CeD. PMID: 24334606
    7. 3q28 rs6444305 in LPP gene is associated with follicular lymphoma. PMID: 25279986
    8. interaction between LPP and alpha-actinin, an actin cross-linking protein, is necessary for TGFbeta-induced migration and invasion of ErbB2-expressing breast cancer cells. PMID: 23447672
    9. Three polymorphisms of LPP gene were selected and replicated in additional 1132 PCOS cases and 1142 controls. Our results suggest that LPP gene might be a novel candidate for PCOS PMID: 23056290
    10. The results suggest that genomic alterations and clearly deleterious sequence changes in the LPP gene are not a common cause of esophageal atresia/tracheoesophageal fistula or VACTERL association. PMID: 22639458
    11. LPP is a nucleocytoplasmatic shuttle protein linking focal adhesion dynamics to the transcriptional machinery. PMID: 19701494
    12. Gene expression levels of bcl-6, lpp and miR-28 are different in various diffuse large B cell lymphoma cell lines. PMID: 19236753
    13. haploinsufficiency of LPP may be a novel cause of conotruncal cardiac anomalies, particularly forms of tetralogy of Fallot PMID: 20949626
    14. LPP contains specific domains that enable its focal adhesion and nuclear targeting capacity PMID: 12441356
    15. Expression of the HMGA2-LPP fusion transcript in only 1 of 61 karyotypically normal pulmonary chondroid hamartomas. PMID: 12505264
    16. LPP and Scrib proteins localize in cell-cell contacts. This interaction links Scrib to a communication pathway between cell-cell contacts and the nucleus, and implicates LPP in Scrib-associated functions PMID: 15649318
    17. Translocation in chromosome 3 and 12 involves fusion of this protein with HMGA2 in pulmonary chondroid hamartoma. PMID: 16271958
    18. HMGA2-LPP fusion promotes chondrogenesis by upregulating cartilage-specific collagen gene expression through the N-terminal DNA binding domains. PMID: 16375854
    19. LPP appears to be a vascular smooth muscle (SMSC) differentiation marker that plays a role in regulating SMC migration. PMID: 16397143
    20. LPP can shuttle between the cytoplasm and the nucleus, suggesting they may transfer information directly from the cytoskeleton or focal adhesions to the transcription machinery. PMID: 16484626
    21. By manipulating LPP levels, we show that it acts to upregulate the transactivation capacity of PEA3. PMID: 16738319
    22. The function of LPP and palladin is context dependent, that they play a critical role in cytoskeletal remodeling, respond to signals induced by vascular injury as well as signals that induce smooth muscle cell hypertrophy, such as angiotension II. PMID: 17322171
    23. expression of LPP and palladin are modulated by a mix of mechanical cues, oxidative stress and substrate composition which translate into their up or down regulation in vessel wall injury and early atherogenesis. PMID: 19205907

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  • 相关疾病：
    A chromosomal aberration involving LPP is associated with a subclass of benign mesenchymal tumors known as lipomas. Translocation t(3;12)(q27-q28;q13-q15) with HMGA2 is shown in lipomas.; DISEASE: Note=A chromosomal aberration involving LPP is associated with pulmonary chondroid hamartomas. Translocation t(3;12)(q27-q28;q14-q15) with HMGA2 is detected in pulmonary chondroid hamartomas.; DISEASE: Note=A chromosomal aberration involving LPP is associated with parosteal lipomas. Translocation t(3;12)(q28;q14) with HMGA2 is also shown in one parosteal lipoma.; DISEASE: Note=A chromosomal aberration involving LPP is associated with acute monoblastic leukemia. Translocation t(3;11)(q28;q23) with KMT2A/MLL1 is associated with acute monoblastic leukemia.
  • 亚细胞定位：
    Nucleus. Cytoplasm. Cell junction. Cell membrane. Note=Found in the nucleus, in the cytoplasm and at cell adhesion sites. Shuttles between the cytoplasm and the nucleus. It has been found in sites of cell adhesion such as cell-to-cell contact and focal adhesion which are membrane attachment sites of cells to the extracellular matrix. Mainly nuclear when fused with HMGA2/HMGIC and KMT2A/MLL1.
  • 蛋白家族：
    Zyxin/ajuba family
  • 组织特异性：
    Expressed in a wide variety of tissues but no or very low expression in brain and peripheral leukocytes.
  • 数据库链接：

    HGNC: 6679

    OMIM: 600700

    KEGG: hsa:4026

    STRING: 9606.ENSP00000318089

    UniGene: Hs.720220