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LRIG3 Antibody

  • 货号：
    CSB-PA570494
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using CSB-PA570494(LRIG3 Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • 其他：

产品详情

  • Uniprot No.：
    Q6UXM1
  • 基因名：
    LRIG3
  • 别名：
    Leucine-rich repeats and immunoglobulin-like domains protein 3 antibody; Leucine-rich repeats- and immunoglobulin-like domains- containing protein 3 antibody; LIG-3 antibody; LIG3 antibody; LRIG1-3 antibody; Lrig3 antibody; LRIG3_HUMAN antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthetic peptide of Human LRIG3
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:1000-1:5000
    IHC 1:25-1:100
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    May play a role in craniofacial and inner ear morphogenesis during embryonic development. May act within the otic vesicle epithelium to control formation of the lateral semicircular canal in the inner ear, possibly by restricting the expression of NTN1.
  • 基因功能参考文献：
    1. Role of LRIG3 in cancer [review] PMID: 27628597
    2. This is the first time a haplotype on chromosome 12 containing sequence variants in the genes DCTN2, DNAH10, LRIG3, and MYO1A has been linked to an inherited neuropathy in humans. PMID: 26517670
    3. LRIG3 functions as a tumor suppressor by attenuating EGFR signaling pathway. PMID: 25708990
    4. LRIG3 plays an important role in Hela229 cell proliferation, apoptosis, and invasiveness. PMID: 26390694
    5. The results on expression of other tumor markers suggest that LRIG3 is influenced by or influences a pattern of tumor markers in cancer and precancerous cells. PMID: 24998916
    6. In conclusion, the over-expression of LRIG3 could influence the cell cycle and invasion, inhibit proliferation and induce apoptosis in the three bladder cancer cell lines. PMID: 23392718
    7. Data indicate that Lrig3 opposes Lrig1 negative regulatory action and enhances ErbB receptors ERBB2, ERBB3 and ERBB4 stability. PMID: 23723069
    8. High LRIG3 expression is associated with cervical adenocarcinoma progression. PMID: 23165628
    9. Silencing LRIG3 inhibited the proliferation and promoted the apoptosis of bladder cancer T24 cells. PMID: 21505989
    10. siRNA targeting LRIG3 gene shows a dramatic inhibitory effect on RNA transcription and protein expression, then promotes the proliferation and suppresses apoptosis of GL15 cells. PMID: 19224171
    11. These results indicate that expression and sub-cellular localization of LRIG1-3 might be of importance in the pathogenesis and prognosis of astrocytic tumors. PMID: 16532360
    12. Down-regulation of LRIG3 in HP75 pituitary adenoma is reported. PMID: 17393120
    13. LRIG proteins may have a role in epidermal homeostasis and psoriasis PMID: 18037903
    14. LRIG3 may be involved in the regulation of EGF receptor signaling, and serve as a tumor suppressor gene in the pathogenesis of glioma. PMID: 19200647
    15. the expression of LRIG1-3 was evaluated in 51 human ependymomas and was found to be more highly expressed in supratentorial than in infratentorial ependymomas PMID: 19216216
    16. Down-regulating LRIG3 gene expression can improve the proliferation of glioma GL15 cells. PMID: 19448407

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  • 亚细胞定位：
    Cell membrane; Single-pass type I membrane protein. Cytoplasmic vesicle membrane; Single-pass type I membrane protein.
  • 组织特异性：
    Widely expressed.
  • 数据库链接：

    HGNC: 30991

    OMIM: 608870

    KEGG: hsa:121227

    STRING: 9606.ENSP00000326759

    UniGene: Hs.253736