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LRRK1 Antibody

  • 货号：
    CSB-PA060159
  • 规格：
    ￥880
  • 其他：

产品详情

  • Uniprot No.：
    Q38SD2
  • 基因名：
    LRRK1
  • 别名：
    KIAA1790 antibody; Leucine rich repeat serine/threonine protein kinase 1 antibody; Leucine-rich repeat serine/threonine-protein kinase 1 antibody; LRRK 1 antibody; Lrrk1 antibody; LRRK1_HUMAN antibody; RIPK6 antibody; Roco1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human LRRK1.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    IHC, IF, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:100-1:300
    IF 1:200-1:1000
    ELISA 1:5000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 基因功能参考文献：
    1. data suggest that LRRK1 variant (rs2924835) and LRRK2 variants (rs34594498, rs34410987, and rs33949390) are not associated with essential tremor in this Han Chinese population PMID: 29812962
    2. LRRK1 plays a critical role in the regulation of bone mass in humans. PMID: 27055475
    3. A novel LRRK1 mutation has been identified in two siblings in an Indian family with osteosclerotic metaphyseal dysplasia. PMID: 27829680
    4. We find that LRRK1-mediated phosphorylation of CLIP-170 causes the accumulation of p150(Glued) (also known as DCTN1) a subunit of dynactin, at microtubule plus ends, thereby facilitating the migration of EGFR-containing endosomes. PMID: 25413345
    5. LRRK1 carries out distinct functions from LRRK2 by interacting with different cellular proteins. PMID: 24947832
    6. LRRK1 mutations may have a role in Parkinson's disease PMID: 24241507
    7. The function of LRRK1 and both the physiological and the pathological roles of LRRK2 are only beginning to unfold. PMID: 22988872
    8. purified and active LRRK1 and LRRK2 can form dimers in their full-length conformation PMID: 22952686
    9. feedback down-regulation of LRRK1 kinase activity by EGFR plays an important role in the appropriate endosomal trafficking of EGFR PMID: 22337768
    10. We report the molecular characterization of human LRRK1 and show for the first time that LRRK1 is a functional protein kinase and a GDP/GTP-binding protein. We propose a model in which LRRK1 cycles between a GTP-bound active and a GDP-bound inactive state PMID: 16243488
    11. Comparison of evolutionary interspecies sequences of LRRK1 and LRRK2 suggests they diverged from a common founder gene implicated in Parkinson disease. PMID: 17225181
    12. Two rare coding variants ss65713826 and ss65713830 were more frequent in patients than controls in norwegain Parkinson's disease. PMID: 17324517
    13. mutations in LRRK2 are more prone to form inclusion bodies in transfected cells and are more toxic than equivalent mutations in LRRK1 PMID: 17394548
    14. LRRK1 genes encode low levels of expressed mRNA corresponding to low levels of protein during development. PMID: 18045479
    15. LRRK1 are active in the adult human cortex cerebri, hippocampus and also seen in the young human thymus. PMID: 18272292
    16. LRRK1 binds GTP and GDP via its Roc domain and autophosphorylation activity is selectively triggered by GTP. Kinase activity was decreased following introduction of mutations homologous to those of LRRK2 that have been associated with Parkinson's disease. PMID: 16243488

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  • 亚细胞定位：
    Cytoplasm.
  • 蛋白家族：
    Protein kinase superfamily, TKL Ser/Thr protein kinase family, ROCO subfamily
  • 数据库链接：

    HGNC: 18608

    OMIM: 610986

    KEGG: hsa:79705

    STRING: 9606.ENSP00000373600

    UniGene: Hs.407918