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  4. LRRTM1 Antibody

LRRTM1 Antibody

  • 货号：
    CSB-PA013187GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q86UE6
  • 基因名：
    LRRTM1
  • 别名：
    4632401D06Rik antibody; AW125451 antibody; FLJ32082 antibody; Leucine rich repeat transmembrane neuronal 1 antibody; Leucine rich repeat transmembrane neuronal 1 protein antibody; Leucine-rich repeat transmembrane neuronal protein 1 antibody; LRRT1_HUMAN antibody; LRRTM1 antibody; Lrrtm1 leucine rich repeat transmembrane neuronal 1 antibody; OTTHUMP00000194829 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human LRRTM1
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Exhibits strong synaptogenic activity, restricted to excitatory presynaptic differentiation, acting at both pre- and postsynaptic level.
  • 基因功能参考文献：
    1. Continuity between schizophrenia and schizotypy exists with regard to the psychological effects of allelic variation in LRRTM1, and epigenetic variation in the imprinted gene mediates the development and expression of human handedness. PMID: 24785688
    2. Hypomethylation of the paternally inherited LRRTM1 promoter is linked to schizophrenia. PMID: 25111784
    3. CTNNA1 and CTNNA2 contain alternative 5' exons linked to bidirectional promoters that are shared with the antisense oriented LRRTM2 and LRRTM1 genes, respectively. PMID: 21708131
    4. 16 SNPs in 12 genes showed significant interaction at P < .05, 3 of which survived correction for multiple testing (P < .0003), situated in AKT1 (rs2494732 and rs1130233) and LRRTM1 (rs673871). PMID: 21041608
    5. Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) PMID: 21041608
    6. Observational study of gene-disease association. (HuGE Navigator) PMID: 20678249
    7. LRRTM1 on chromosome 2p12 is a maternally suppressed gene that is associated paternally with handedness and schizophrenia. PMID: 17667961
    8. Whether or not LRRTM1 on chromosome 2p12 is indeed the genetic basis of handedness is still unclear, although the controversy of the claim seems indisputable. PMID: 19125365
    9. While we agree (and indeed first proposed) that the variation underlying psychosis is intrinsically related to the cerebral torque, which we take to be the anatomical basis of language, we are unconvinced by the data for LRRTM1. PMID: 19125366
    10. Recent study in which the first putative genetic effect on human handedness was identified (the imprinted locus LRRTM1 on human chromosome 2). PMID: 19125367
    11. Results strengthen the evidence for an association of imprinted alleles of LRRTM1 with schizophrenia. Weaker supportive evidence was also obtained for a possible association of LRTTM1 with human brain asymmetry. PMID: 19626025

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  • 亚细胞定位：
    Cell membrane; Single-pass type I membrane protein. Cell junction, synapse, postsynaptic cell membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    LRRTM family
  • 组织特异性：
    Predominantly expressed in forebrain regions including thalamus and cerebral cortex.
  • 数据库链接：

    HGNC: 19408

    OMIM: 610867

    KEGG: hsa:347730

    STRING: 9606.ENSP00000295057

    UniGene: Hs.591580