Your Good Partner in Biology Research

  1. Home
  2. 抗体
  3. 多克隆抗体
  4. LSM14A Antibody

LSM14A Antibody

  • 货号：
    CSB-PA013203GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q8ND56
  • 基因名：
    LSM14A
  • 别名：
    AlphaSNBP antibody; C19orf13 antibody; Chromosome 19 open reading frame 13 antibody; DKFZp434D1335 antibody; FAM61A antibody; Family with sequence similarity 61 member A antibody; hRAP55 antibody; hRAP55A antibody; LS14A_HUMAN antibody; LSM14 homolog A (SCD6 S cerevisiae) antibody; LSM14 homolog A antibody; LSM14A antibody; Protein FAM61A antibody; Protein LSM14 homolog A antibody; Protein SCD6 homolog antibody; Putative alpha synuclein binding protein antibody; Putative alpha-synuclein-binding protein antibody; RAP55 antibody; RNA associated protein 55 antibody; RNA-associated protein 55A antibody; SCD6 homolog A (S cerevisiae) antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human LSM14A
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Essential for formation of P-bodies, cytoplasmic structures that provide storage sites for translationally inactive mRNAs and protect them from degradation. Acts as a repressor of mRNA translation. May play a role in mitotic spindle assembly.
  • 基因功能参考文献：
    1. alpha-synuclein p.A53V homozygous mutation leads to a distinct phenotype of progressive parkinsonism and cognitive decline, commonly observed in patients with SNCA missense mutation or multiplications PMID: 28666710
    2. Excessive iron and alpha-synuclein oligomer in brain commonly contributed to pure apathy of PD through potential mechanism of oxidative stress. PMID: 26940028
    3. RAP55/LSM14 binds directly the tubulin and that is implicated in the process of the mitotic spindle stabilization PMID: 26339800
    4. RAP55 is important for the assembly of cytoplasmic mRNP granules and that PRMT1 is required for RAP55A to localize to P-bodies. PMID: 22614839
    5. The NS1 protein of influenza A virus interacts with cellular processing bodies and stress granules through RNA-associated protein 55 (RAP55) during virus infection. PMID: 22973032
    6. LSm14A is a processing body-associated sensor of viral nucleic acids that initiates cellular antiviral response in the early phase of viral infection. PMID: 22745163
    7. this protein family has evolved a common and fundamental role in the control of mRNA translation. Human RAP55A is an autoantigen detected in the serum of patients with primary biliary cirrhosis (PBC). PMID: 18723115

    显示更多

    收起更多

  • 亚细胞定位：
    Cytoplasm, P-body. Cytoplasm, cytoskeleton, spindle. Cytoplasm, Stress granule.
  • 蛋白家族：
    LSM14 family
  • 数据库链接：

    HGNC: 24489

    OMIM: 610677

    KEGG: hsa:26065

    STRING: 9606.ENSP00000413964

    UniGene: Hs.744009