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LSS Antibody

  • 货号：
    CSB-PA013216ESR1HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human liver cancer using CSB-PA013216ESR1HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human placenta tissue using CSB-PA013216ESR1HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) LSS Polyclonal antibody
  • Uniprot No.：
    P48449
  • 基因名：
    LSS
  • 别名：
    LSS antibody; OSCLanosterol synthase antibody; EC 5.4.99.7 antibody; 2,3-epoxysqualene--lanosterol cyclase antibody; Oxidosqualene--lanosterol cyclase antibody; OSC antibody; hOSC antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Lanosterol synthase protein (1-300AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Key enzyme in the cholesterol biosynthesis pathway. Catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol nucleus. Through the production of lanosterol may regulate lens protein aggregation and increase transparency.
  • 基因功能参考文献：
    1. LSS gene mutation is associated with Congenital cataract. PMID: 29016354
    2. Lanosterol synthase gene polymorphisms influence both the salt sensitivity of BP and changes in circulating EO in response to a low salt diet. PMID: 26667413
    3. There were no significant differences in OSC mRNA expression at various stages of breast cancer, or between tumor and normal mammary cells. PMID: 25051231
    4. oxidosqualene cyclase is active as a monomer PMID: 14766201
    5. two crystal structures of the human membrane protein OSC: the target protein with an inhibitor that showed cholesterol lowering in vivo opens the way for the structure-based design of new OSC inhibitors PMID: 15525992
    6. Suppression of 2,3-oxidosqualene cyclase by high fat diet contributes to liver X receptor-alpha-mediated improvement of hepatic lipid profile. PMID: 19119143

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  • 相关疾病：
    Cataract 44 (CTRCT44)
  • 亚细胞定位：
    Endoplasmic reticulum membrane; Peripheral membrane protein.
  • 蛋白家族：
    Terpene cyclase/mutase family
  • 组织特异性：
    Widely expressed. Expressed in the hair bulb, the outer root sheath and hair matrix of the hair follicle epithelium. Also detected in dermal papilla, epidermis, sweat glands, sebaceous glands, and blood vessels.
  • 数据库链接：

    HGNC: 6708

    OMIM: 600909

    KEGG: hsa:4047

    STRING: 9606.ENSP00000348762

    UniGene: Hs.596543