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LTB Antibody

  • 货号：
    CSB-PA823426
  • 规格：
    ￥880
  • 图片：
    • Immunohistochemical analysis of paraffin-embedded human-liver, antibody was diluted at 1:200
    • Immunohistochemical analysis of paraffin-embedded human-spleen, antibody was diluted at 1:200
    • Immunohistochemical analysis of paraffin-embedded human-spleen, antibody was diluted at 1:200
  • 其他：

产品详情

  • Uniprot No.：
    Q06643
  • 基因名：
  • 别名：
    LT beta antibody; LT-beta antibody; Ltb antibody; lymphotoxin beta antibody; Lymphotoxin-beta antibody; p33 antibody; TNF-C antibody; TNFC antibody; TNFC_HUMAN antibody; TNFSF3 antibody; Tumor necrosis factor C antibody; Tumor necrosis factor ligand superfamily member 3 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthetic peptide from Human protein at AA range: 41-90
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 纯化方式：
    The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol.
  • 产品提供形式：
    Liquid
  • 应用范围：
    IHC,ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    IHC IHC-p:1:50-300
    ELISA 1:10000-20000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Cytokine that binds to LTBR/TNFRSF3. May play a specific role in immune response regulation. Provides the membrane anchor for the attachment of the heterotrimeric complex to the cell surface. Isoform 2 is probably non-functional.
  • 基因功能参考文献：
    1. Combination of an EGFR tyrosine kinase inhibitor and a NF-kappaB inhibitor effectively suppressed cetuximab-resistant HNSCC and interfering with the EGFR-LTbeta interaction reverses resistance. PMID: 28196873
    2. TNF is able to upregulate LT-beta expression in hepatic cells at the transcriptional level by the binding of NF-kappaB p50/p65 heterodimers and Ets1 to their respective sites in the LT-beta promoter. PMID: 22742857
    3. The multifaceted character of lymphotoxin beta may be involved in inflammatory myopathies and muscular dystrophies. PMID: 22652080
    4. Data show differential expression of interferon-gamma, TNFSF3, TNFSF10, TNFSF12 and PDGFbeta in CD8+, CD14+ and CD4+ cells. PMID: 21211989
    5. Findings provide evidence of additional complexity in the transcriptional regulation of LTB with implications for coordinate expression of genes in this important genomic locus. PMID: 21248773
    6. Heterotypic interaction between LTbeta-producing lymphocytes and responding fibroblast-like synoviocytes contributes to establishment of complex lymphoid microstructures. May be one element in susceptibility of synovial membrane to lymphoid organogenesis. PMID: 15248211
    7. The identification of IL-6 and IL-1beta as activators of LT-beta supports their involvement in LT-beta signaling in liver regeneration associated with chronic liver damage. PMID: 15910501
    8. Lymphotoxin (LT) beta receptor ligands LTalpha1 and -beta2 activate both the classical and noncanonical NF-kappa B pathways in human vascular endothelial cells and dermal microvascular endothelial cells in vitro. PMID: 18292573
    9. LT-Beta may play a role in rheumatoid arthritis disease pathogenesis by contributing to a more intense inflammatory reaction in the synovium PMID: 18379788
    10. blocking the lymphotoxin-beta receptor pathway results in ablation of the lymphoid organization in the NOD salivary glands and thus an improvement in salivary gland function. PMID: 19222863

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  • 亚细胞定位：
    Membrane; Single-pass type II membrane protein.
  • 蛋白家族：
    Tumor necrosis factor family
  • 组织特异性：
    Spleen and thymus.
  • 数据库链接：

    HGNC: 6711

    OMIM: 600978

    KEGG: hsa:4050

    STRING: 9606.ENSP00000410481

    UniGene: Hs.376208