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  4. LXN Antibody

LXN Antibody

  • 货号：
    CSB-PA533514
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using CSB-PA533514(LXN Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA533514(LXN Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: ×200)
    • Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane: A549 cells, Primary antibody: CSB-PA533514(LXN Antibody) at dilution 1/667, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 seconds
  • 其他：

产品详情

  • Uniprot No.：
    Q9BS40
  • 基因名：
    LXN
  • 别名：
    ECI antibody; Endogenous carboxypeptidase inhibitor antibody; Latexin antibody; Latexin protein antibody; LXN antibody; LXN_HUMAN antibody; MUM antibody; Protein MUM antibody; TCI antibody; Tissue carboxypeptidase inhibitor antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Fusion protein of Human LXN
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:2000-1:10000
    WB 1:1000-1:5000
    IHC 1:25-1:100
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Hardly reversible, non-competitive, and potent inhibitor of CPA1, CPA2 and CPA4. May play a role in inflammation.
  • 基因功能参考文献：
    1. Results identified that LXN expression inversely modulates taxane-chemoresistance in the PC-3 prostate cancer cell line. Inhibition of LXN expression in the bone microenvironment promotes chemoresistance, in part through a methylation-dependent mechanism. PMID: 28087740
    2. Results show that Lxn expression was clearly decreased in the pancreatic ductal adenocarcinoma tissues suggesting it that as a tumor suppressor that targets CD133-positive cancer cells. PMID: 26530530
    3. Lxn protein and mRNA expression levels in CD133+ miapaca-2 cells were significantly lower than those in CD133- cells. PMID: 25551472
    4. latexin is markedly downregulated in hepatocellular carcinoma specimens, compared to adjacent non-cancerous tissues. PMID: 24399246
    5. CD146 and Lxn increased tumor migration and invasion of thyroid cancer. PMID: 23712706
    6. The hematopoietic stem cell regulatory gene latexin has tumor-suppressive properties in malignant melanoma. PMID: 23364479
    7. These results are consistent with a tumor suppressor role for latexin. PMID: 23028717
    8. Latexin expression is lost or greatly reduced in approximately 50% of human leukemia/lymphoma cell lines. PMID: 21567403
    9. downregulated expression in gastric carcinomas; tumor suppressor PMID: 21466706

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  • 亚细胞定位：
    Cytoplasm.
  • 蛋白家族：
    Protease inhibitor I47 (latexin) family
  • 组织特异性：
    Highly expressed in heart, prostate, ovary, kidney, pancreas, and colon, moderate or low in other tissues including brain.
  • 数据库链接：

    HGNC: 13347

    OMIM: 609305

    KEGG: hsa:56925

    STRING: 9606.ENSP00000264265

    UniGene: Hs.478067