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LZTFL1 Antibody

  • 货号：
    CSB-PA885687LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in: HEK293 whole cell lysate, HepG2 whole cell lysate, Hela whole cell lysate, U251 whole cell lysate
      All lanes: LZTFL1 antibody at 3µg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 35, 33, 30 kDa
      Observed band size: 35, 50 kDa
    • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA885687LA01HU at dilution of 1:100
    • Immunofluorescent analysis of U251 cells using CSB-PA885687LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
    • Immunoprecipitating LZTFL1 in HepG2 whole cell lysate
      Lane 1: Rabbit control IgG instead of CSB-PA885687LA01HU in HepG2 whole cell lysate. For western blotting, a HRP-conjugated light chain specific antibody was used as the Secondary antibody (1/50000)
      Lane 2: CSB-PA885687LA01HU (4µg) + HepG2 whole cell lysate (500µg)
      Lane 3: HepG2 whole cell lysate (20µg)
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) LZTFL1 Polyclonal antibody
  • Uniprot No.：
    Q9NQ48
  • 基因名：
    LZTFL1
  • 别名：
    5530402H04Rik antibody; 6130400H19Rik antibody; AI414725 antibody; AW048545 antibody; BBS17 antibody; DKFZp686H2076 antibody; FLJ36386 antibody; Leucine zipper transcription factor like 1 antibody; Leucine zipper transcription factor like protein 1 antibody; Leucine zipper transcription factor-like protein 1 antibody; LZTFL 1 antibody; Lztfl1 antibody; Lztfl1 leucine zipper transcription factor-like 1 antibody; LZTL1_HUMAN antibody; MGC106871 antibody; MGC108960 antibody; Putative uncharacterized protein DKFZp686H2076 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Leucine zipper transcription factor-like protein 1 protein (116-299AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，LZTFL1 Antibody (CSB-PA885687LA01HU)，的标记方式是Non-conjugated。对于LZTFL1 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA885687LB01HU LZTFL1 Antibody, HRP conjugated ELISA
    FITC CSB-PA885687LC01HU LZTFL1 Antibody, FITC conjugated
    Biotin CSB-PA885687LD01HU LZTFL1 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC, IF, IP
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:20-1:200
    IF 1:50-1:200
    IP 1:200-1:2000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Regulates ciliary localization of the BBSome complex. Together with the BBSome complex, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. May play a role in neurite outgrowth. May have tumor suppressor function.
  • 基因功能参考文献：
    1. LZTFL1 inhibits lung tumorigenesis PMID: 26364604
    2. these data indicate that LZTFL1 modulates T cell activation and IL-5 levels. PMID: 26700766
    3. LZTFL1 binds beta-catenin in the cytoplasm of the cell and inhibited its nuclear translocation PMID: 25005785
    4. This special subtype of polydactyly in BBS patients is easily identified on clinical examination and prompts for priority sequencing of LZTFL1 (BBS17). PMID: 23692385
    5. The absence of LZTFL1 leads to a BBS phenotype with enhanced developmental abnormalities associated with cellular Shh dysfunction. LZTFL1 is a novel BBS gene (BBS17). PMID: 22510444
    6. Our findings suggest that LZTFL1 is an important regulator of BBSome ciliary trafficking and hedgehog signaling PMID: 22072986
    7. LZTFL1 may inhibit tumorigenesis by stabilizing E-cadherin-mediated adherens junction formation and promoting epithelial cell differentiation. PMID: 20233871

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  • 相关疾病：
    Bardet-Biedl syndrome 17 (BBS17)
  • 亚细胞定位：
    Cytoplasm.
  • 蛋白家族：
    LZTFL1 family
  • 组织特异性：
    Expressed in prostate, ovary, stomach, pancreas, esophagus, breast, liver, bladder, kidney, thyroid, colon and lung (at protein level). Down-regulated in multiple primary tumors (at protein level). Detected in testis, heart, skeletal muscle, thymus, splee
  • 数据库链接：

    HGNC: 6741

    OMIM: 606568

    KEGG: hsa:54585

    STRING: 9606.ENSP00000296135

    UniGene: Hs.30824