Your Good Partner in Biology Research

  1. Home
  2. 抗体
  3. 多克隆抗体
  4. MAGEA6 Antibody

MAGEA6 Antibody

  • 货号：
    CSB-PA013332ESR2HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: MAGEA6 antibody at 7μg/ml
      Lane 1: Rat brain tissue
      Lane 2: Rat gonad tissue
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 35 kDa
      Observed band size: 35 kDa
    • Immunohistochemistry of paraffin-embedded human lung cancer using CSB-PA013332ESR2HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA013332ESR2HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) MAGEA6 Polyclonal antibody
  • Uniprot No.：
    P43360
  • 基因名：
    MAGEA6
  • 别名：
    MAGEA6 antibody; MAGE6 antibody; Melanoma-associated antigen 6 antibody; Cancer/testis antigen 1.6 antibody; CT1.6 antibody; MAGE-6 antigen antibody; MAGE3B antigen antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Rat
  • 免疫原：
    Recombinant Human Melanoma-associated antigen 6 protein (75-314AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Activator of ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases that acts as a as repressor of autophagy. May enhance ubiquitin ligase activity of TRIM28 and stimulate p53/TP53 ubiquitination by TRIM28. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. May play a role in tumor transformation or aspects of tumor progression. In vitro promotes cell viability in melanoma cell lines.
  • 基因功能参考文献：
    1. MAGEA6 knockdown by targeted-shRNA induced AMPK stabilization and activation, which led to mTOR complex 1 (mTORC1) in-activation and RCC cell death/apoptosis. PMID: 29448247
    2. MAGEA6 promotes glioma cell survival possibly via targeting AMPKalpha1. PMID: 29024810
    3. MageA6 and MageA11 form a protein complex resulting in the stabilization of MageA11 and consequently the enhancement of androgen receptor activity. PMID: 28542476
    4. To identify novel CTL epitopes from MAGE-A6 and MAGE-A12 antigens. PMID: 22707303
    5. Disease-associated bias in T helper type 1 (Th1)/Th2 CD4(+) T cell responses against MAGE-6 in HLA-DRB10401(+) patients with renal cell carcinoma or melanoma. PMID: 12208877
    6. MAGE-6 encodes HLA-DRbeta1*0401-presented epitopes recognized by CD4+ T cells from patients with melanoma or renal cell carcinoma PMID: 12631591

    显示更多

    收起更多

  • 组织特异性：
    Expressed in many tumors of several types, such as melanoma, head and neck squamous cell carcinoma, lung carcinoma and breast carcinoma, but not in normal tissues except for testes.
  • 数据库链接：

    HGNC: 6804

    OMIM: 300176

    KEGG: hsa:4105

    STRING: 9606.ENSP00000329199

    UniGene: Hs.441113