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MAGEA9 Antibody

  • 货号：
    CSB-PA009980
  • 规格：
    ￥880
  • 其他：

产品详情

  • Uniprot No.：
    P43362
  • 基因名：
    MAGEA9
  • 别名：
    Cancer/testis antigen 1.9 antibody; Cancer/testis antigen family 1 member 9 antibody; CT1.9 antibody; MAGA9_HUMAN antibody; MAGE 9 antigen antibody; MAGE-9 antigen antibody; MAGE9 antibody; MAGEA9A antibody; MAGEA9B antibody; Melanoma antigen family A 9 antibody; Melanoma associated antigen 9 antibody; Melanoma-associated antigen 9 antibody; MGC8421 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthesized peptide derived from the N-terminal region of Human MAGE-9.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    IHC, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:100-1:300
    ELISA 1:40000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Not known, though may play a role in embryonal development and tumor transformation or aspects of tumor progression.
  • 基因功能参考文献：
    1. MAGE-A9 overexpression promoted cell proliferation, colony formation, migration, chemoresistance, and tumorigenicity in the context of EpCAM+ HCC cells, whereas MAGE-A9 knockdown significantly inhibited anchorage-dependent and spheroid colony formation and in vivo tumorigenicity. PMID: 29138811
    2. potential X-linked candidate for the CNV67-related spermatogenic failure phenotype PMID: 28339631
    3. High expression levels of MAGE-A9 are correlated with lung adenocarcinoma. PMID: 26717042
    4. The results showed that the high expression of MAGE-A9 protein in NSCLC tumor cells were commonly present in squamous cell carcinomas. It was also related to larger tumor diameter, lymph node metastasis and later stage grouping with TNM classification PMID: 25755744
    5. These data are the first to indicate that MAGE-A9 expression is a valuable prognostic biomarker for HCC and that high MAGE-A9 expression suggests unfavorable survival outcomes in HCC patients PMID: 25315972
    6. High expression of MAGE-A9 indicates unfavorable survival outcome in laryngeal squamous cell carcinoma patients. PMID: 25400753
    7. The data suggest that MAGE-A9 expression is correlated with malignant attributes of invasive ductal breast cancer PMID: 25445503
    8. MAGE-A9 and MAGE-A11 are tumor-specific antigens and not only DNA hypermethylation but also histone deacetylation is responsible for the mechanism underlying MAGE-A9 and MAGE-A11 gene silencing. PMID: 24316396
    9. May provide suitable targets for immunotherapy of renal cell carcinoma. PMID: 15900605
    10. Overexpression of MAGE-A9 is associated with bladder cancer. PMID: 19533752

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  • 组织特异性：
    Expressed in many tumors of several types, such as melanoma, head and neck squamous cell carcinoma, lung carcinoma and breast carcinoma, but not in normal tissues except for testes and placenta.
  • 数据库链接：

    HGNC: 6807

    OMIM: 300342

    KEGG: hsa:4108

    STRING: 9606.ENSP00000298974

    UniGene: Hs.460974