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MAGI1 Antibody

  • 货号：
    CSB-PA857014LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunofluorescence staining of HepG2 cells with CSB-PA857014LA01HU at 1:133, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) MAGI1 Polyclonal antibody
  • Uniprot No.：
    Q96QZ7
  • 基因名：
  • 别名：
    AIP 3 antibody; AIP-3 antibody; AIP3 antibody; Atrophin 1 interacting protein 3 antibody; Atrophin-1-interacting protein 3 antibody; BAI1 associated protein 1 antibody; BAI1-associated protein 1 antibody; BAIAP 1 antibody; BAIAP1 antibody; BAP 1 antibody; BAP-1 antibody; BAP1 antibody; Gukmi1 antibody; MAGI 1 antibody; MAGI-1 antibody; MAGI1 antibody; MAGI1_HUMAN antibody; MAGI1c antibody; Membrane associated guanylate kinase inverted 1 antibody; membrane associated guanylate kinase WW and PDZ domain containing 1 antibody; Membrane-associated guanylate kinase antibody; Membrane-associated guanylate kinase inverted 1 antibody; TNRC 19 antibody; TNRC19 antibody; Trinucleotide repeat containing gene 19 antibody; Trinucleotide repeat containing gene 19 protein antibody; Trinucleotide repeat-containing gene 19 protein antibody; WW and PDZ domain-containing protein 1 antibody; WW domain containing protein 3 antibody; WW domain-containing protein 3 antibody; WWP 3 antibody; WWP3 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 protein (1234-1367AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，MAGI1 Antibody (CSB-PA857014LA01HU)，的标记方式是Non-conjugated。对于MAGI1 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA857014LB01HU MAGI1 Antibody, HRP conjugated ELISA
    FITC CSB-PA857014LC01HU MAGI1 Antibody, FITC conjugated
    Biotin CSB-PA857014LD01HU MAGI1 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    May play a role as scaffolding protein at cell-cell junctions. May regulate acid-induced ASIC3 currents by modulating its expression at the cell surface.
  • 基因功能参考文献：
    1. Decreased MAGI1 expression in the colonic mucosa might contribute to the pathogenesis of microscopic colitis. PMID: 29204743
    2. it negatively controls the cell growth of various types of cells and positively controls cell-cell interaction and the decreased expression of MAGI-1 in human T cells contributes to the development of several types of T-cell leukemia, partly through the stimulation of the Akt and MEK pathways. PMID: 29043551
    3. Study presented a combined molecular dynamics/infrared spectroscopy approach to the study of ligand binding (11-residue peptide derived from the C terminus of HPV16 E6) by the PDZ1 domain of MAGI1, focusing in particular on the far-infrared region of the spectrum. PMID: 28636914
    4. Here we present the result of a 4-stage genome-wide association study composed of 5,953 adolescent idiopathic scoliosis patients and 8,137 controls. Overall, we identified three novel susceptible loci including rs7593846 at 2p14 near MEIS1 , rs7633294 at 3p14.1 near MAGI1 and rs9810566 at 3q26.2 near TNIK PMID: 28334814
    5. A deletion at ADAMTS9-MAGI1 locus is associated with psoriatic arthritis risk. PMID: 25990289
    6. MAGI1 rs35855737 is a novel locus for neuroticism. [Meta-Analysis] PMID: 25993607
    7. Variants in MAGI1 were associated with a Crohn's disease phenotype involving a complicated stricturing disease course. PMID: 25557950
    8. The data suggests that inactivation of MAGI-1 by the NS1 protein from avian influenza A virus elicits an interferon-beta induction signal. PMID: 22911767
    9. The PDZ1 and PDZ3 domains of MAGI-1 regulate the eight-exon isoform of the CXADR-like membrane protein. PMID: 22718816
    10. MAGI1 may inhibit the cancer cell migration and invasion of hepatocellular carcinoma via regulating PTEN. PMID: 21685691
    11. Results presented herein provide further evidence for a role of MAGI1 in bipolar affective disorder and schizophrenia etiology. PMID: 22381734
    12. MAGI1 expression is decreased in hepatocellular carcinoma, which correlates with poor prognosis, suggesting MAGI1 as a novel prognostic marker PMID: 21942217
    13. HPV16 E6 association with PDZ domain-containing proteins, MAGI1, Dlg1 or Scrib, stabilized the levels of E6. PMID: 21489588
    14. Mutations designed in the C-terminal flanking region of the human MAGI-1 PDZ domain resulted in a significant decrease in binding affinity for human papillomavirus E6 peptides. PMID: 21238461
    15. These results demonstrate that oncogenic HPV E6 proteins disrupt cellular tight junctions through the degradation of MAGI-1. PMID: 21123374
    16. Data conclude that the up-regulation of sdk-1 in podocytes is an important pathogenic factor in glomerulosclerosis and that the mechanism involves disruption of the actin cytoskeleton possibly via alterations in MAGI-1 function. PMID: 20562105
    17. interaction with synaptopodin and alpha-actinin-4 PMID: 12042308
    18. Dll1 is presented on the surface of AJs formed at the apical termini of processes through interaction with MAGI1 to activate Notch on neighboring cells in the developing central nervous system PMID: 15908431
    19. In vitro binding assays using the partial cDNA as a GST fusion protein confirm the binding to full-length MAGI-1 expressed in HEK293 cells. PMID: 16019084
    20. MAGI-1 is important for vascular endothelial-cadherin-dependent Rap1 activation upon cell-cell contact. PMID: 16339077
    21. MAGI-1 cleavage appears to be an important step in the disassembly of cell-cell contacts during apoptosis. PMID: 17191119
    22. Structural basis for controlling the dimerization and stability of the WW domains of MAGI1 is reported. PMID: 18562638

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  • 亚细胞定位：
    Cell junction, tight junction. Cell membrane; Peripheral membrane protein. Note=Localizes to epithelial cells tight junctions.
  • 组织特异性：
    Widely expressed with the exception of skeletal muscle. Isoform 1, isoform 2 and isoform 6 are highly expressed in colon, kidney, lung, liver, and pancreas. Isoform 5 is predominantly expressed in brain and heart. Isoform 3 and isoform 4 are highly expres
  • 数据库链接：

    HGNC: 946

    OMIM: 602625

    KEGG: hsa:9223

    STRING: 9606.ENSP00000385450

    UniGene: Hs.476636