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MAGI2 Antibody

  • 货号：
    CSB-PA080079
  • 规格：
    ￥880
  • 其他：

产品详情

  • Uniprot No.：
    Q86UL8
  • 基因名：
  • 别名：
    Activin receptor interacting protein 1 antibody; Acvri1 antibody; Acvrinp1 antibody; ACVRIP1 antibody; AIP 1 antibody; Aip-1 antibody; ARIP1 antibody; Atrophin 1 interacting protein 1 antibody; Atrophin 1 interacting protein A antibody; Atrophin-1-interacting protein 1 antibody; Atrophin-1-interacting protein A antibody; KIAA0705 antibody; MAGI-2 antibody; MAGI2 antibody; MAGI2_HUMAN antibody; Membrane associated guanylate kinase 2 antibody; Membrane associated guanylate kinase inverted 2 antibody; Membrane associated guanylate kinase WW and PDZ domain containing 2 antibody; Membrane associated guanylate kinase WW and PDZ domain containing protein 2 antibody; Membrane-associated guanylate kinase antibody; Membrane-associated guanylate kinase inverted 2 antibody; S SCAM antibody; SSCAM antibody; WW and PDZ domain-containing protein 2 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human MAGI-2.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, IHC, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:20000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Seems to act as scaffold molecule at synaptic junctions by assembling neurotransmitter receptors and cell adhesion proteins. May play a role in regulating activin-mediated signaling in neuronal cells. Enhances the ability of PTEN to suppress AKT1 activation. Plays a role in nerve growth factor (NGF)-induced recruitment of RAPGEF2 to late endosomes and neurite outgrowth.
  • 基因功能参考文献：
    1. MAGI2-AS3 plays an important role as a tumour suppressor by targeting Fas and FasL signalling. PMID: 29679339
    2. MAGI-2 immunoreactivity is elevated in prostate cancer and high-grade prostatic intraepithelial neoplasia compared with normal tissue, suggesting that MAGI-2 may contribute to prostate carcinogenesis. PMID: 26980016
    3. Immunohistochemistry in kidney sections from these patients revealed that mutations resulted in lack of or diminished podocyte MAGI2 expression. Our data support the finding that mutations in the MAGI2 gene are causal for congenital steroid-resistant nephrotic syndrome PMID: 27932480
    4. MAGI-2 could represent a useful adjunct for diagnosis of prostatic adenocarcinoma PMID: 27543977
    5. The expression of MAGI2 mRNA was significantly down-regulated in PC3, LNCaP and DU-145 PCa cell lines. PMID: 24985972
    6. MAGI2, SERPINE2, and NT5C3B expression levels are associated with airway wall thickening and additionally with bronchial inflammation, emphysema, and lung function, respectively, all features of chronic obstructive pulmonary disease. PMID: 25517131
    7. Data show that the miR-134/487b/655 cluster regulates TGF-beta1-induced epithelial-mesenchymal transition and affected the resistance to gefitinib by directly targeting membrane-associated guanylate kinase, WW, and PDZ domain-containing protein 2 (MAGI2). PMID: 24258346
    8. In Usher syndrome 1G, mutations in SANS eliminate Magi2 binding and thereby deregulate endocytosis, lead to defective ciliary transport modules and ultimately disrupt photoreceptor cell function inducing retinal degeneration. PMID: 24608321
    9. MAGI2 enhances the sensitivity of BEL-7404 human hepatocellular carcinoma cells to staurosporine-induced apoptosis by increasing PTEN stability. PMID: 23754155
    10. Common variants in MAGI2 gene are associated with increased risk for cognitive impairment in schizophrenic patients. PMID: 22649501
    11. Results presented herein provide further evidence for a role of MAGI2 in bipolar affective disorder and schizophrenia etiology. PMID: 22381734
    12. Interstitial deletions that include the MAGI2 gene on chromosome 7q11.23-q.21.11 are associated with IS cases. PMID: 18565486
    13. there was no association of MAGI2 and PARD3 with IBD. PMID: 21515326
    14. analysis of 7q11.21-q11.23 and infantile spasms without deletion of MAGI2 [case report] PMID: 20101691
    15. Data show that AIP1 is a novel GTPase-activating protein for Arf6, a small GTPase regulating cellular PIP(2) production and formation of the TLR4-TIRAP-MyD88 complex. PMID: 19948740
    16. PTEN plays a critical role in MAGI-2-induced inhibition of cell migration and proliferation in human hepatocarcinoma cells PMID: 17880912
    17. MAGI2 genetic variation is associated with inflammatory bowel disease. PMID: 18720471

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  • 相关疾病：
    Nephrotic syndrome 15 (NPHS15)
  • 亚细胞定位：
    Cytoplasm. Late endosome. Cell junction, synapse, synaptosome. Cell membrane; Peripheral membrane protein.
  • 蛋白家族：
    MAGUK family
  • 组织特异性：
    Specifically expressed in brain.
  • 数据库链接：

    HGNC: 18957

    OMIM: 606382

    KEGG: hsa:9863

    STRING: 9606.ENSP00000346151

    UniGene: Hs.603842