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MAML1 Antibody

  • 货号：
    CSB-PA838784LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human skin tissue using CSB-PA838784LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human pancreatic tissue using CSB-PA838784LA01HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) MAML1 Polyclonal antibody
  • Uniprot No.：
    Q92585
  • 基因名：
  • 别名：
    Mam-1 antibody; Mam1 antibody; MAML 1 antibody; Maml1 antibody; MAML1_HUMAN antibody; Mastermind like 1 antibody; Mastermind-like protein 1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Mastermind-like protein 1 protein (1-45AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，MAML1 Antibody (CSB-PA838784LA01HU)，的标记方式是Non-conjugated。对于MAML1 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA838784LB01HU MAML1 Antibody, HRP conjugated ELISA
    FITC CSB-PA838784LC01HU MAML1 Antibody, FITC conjugated
    Biotin CSB-PA838784LD01HU MAML1 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Enhances phosphorylation and proteolytic turnover of the NOTCH intracellular domain in the nucleus through interaction with CDK8. Binds to CREBBP/CBP which promotes nucleosome acetylation at NOTCH enhancers and activates transcription. Induces phosphorylation and localization of CREBBP to nuclear foci. Plays a role in hematopoietic development by regulating NOTCH-mediated lymphoid cell fate decisions.
  • 基因功能参考文献：
    1. Our results showed that MEIS1 may have a negative role in regulation of MAML1expression during the esophageal squamous cell carcinoma progression. PMID: 28462489
    2. s report that p300 and CBP acetylate Mastermind-like 1 (Maml1) on amino acid residues K188 and K189 to recruit NACK to the Notch1 ternary complex, which results in the recruitment of RNA polymerase II to initiate transcription. PMID: 28625977
    3. Overexpression of Mastermind like1 was detected in 59% of tumor samples PMID: 28325367
    4. MAML1 may play an important role in tumor progression of Hepatocellular Carcinoma. PMID: 27650617
    5. The transcriptional coregulator MAML1 affects DNA methylation and gene expression patterns in human embryonic kidney cells. PMID: 26857655
    6. MMAL1 overexpression is associated with Esophageal Squamous Cell Carcinoma. PMID: 26294058
    7. study identifies that MAML1 is ubiquitinated in the absence of Notch signaling to maintain low levels of MAML1 in the cell PMID: 26225565
    8. In MCF-7 cells p53 associates with the Notch transcriptional complex (NTC) in a MAML1-dependent fashion, most likely through a p53-MAML1 interaction. PMID: 26033683
    9. The impact of MAML1 genetic variants to heart rate was discovered. PMID: 24680774
    10. Data indicate that EpCAM, CK19, and hMAM triple-marker-positive circulating tumor cells (CTCs) were detected in 86 of 98 (87.8 %) patients. PMID: 22990361
    11. Snail decreased transcription of Notch1 intracellular domain (NICD) target genes via competing with MAML1, co-activator, in NICD complex. PMID: 23454378
    12. s report that human papillomavirus type 8 E6 subverts NOTCH activation during keratinocyte differentiation by inhibiting RBPJ/MAML1 transcriptional activator complexes at NOTCH target DNA. PMID: 23365452
    13. This study demonstrated that targeting Maml1-induced tumor cell senescence and differentiation may alter the tumor microenvironment and cytokine and chemokine profiles and may also promote innate and adaptive immune cell infiltration and function. PMID: 22864395
    14. Bioinformatics assessment revealed a correlation between p300, EGR1 and MAML1 copy number and mRNA alterations in renal clear cell carcinoma and p300, EGR1 and MAML1 gene alterations were associated with increased overall survival. PMID: 23029358
    15. MAML1 is best known as the co-activator and effector of NOTCH-induced transcription, and BPV-1 E6 represses synthetic NOTCH-responsive promoters, endogenous NOTCH-responsive promoters, and is found in a complex with MAML1 in stably transformed cells PMID: 22249263
    16. Overexpression of MAML-1 and Twist1 were significantly associated with lymph node metastasis and the surgical staging of tumor PMID: 22006371
    17. Association of CSL with NICD exerts remarkably little effect on the exchange kinetics of the ANK domain, whereas MAML1 binding greatly retards the exchange kinetics of ANK repeats 2-3. PMID: 22325781
    18. MAML1 increases Notch acetylation by potentiating p300 autoacetylation. PMID: 22100894
    19. To target Notch signaling using MAML1 treatment may present a novel method to control cell viability in cervical cancer cells. PMID: 21640102
    20. Data show no detectable difference in the DNA binding site preferences of CSL before and after loading of four different Notch receptors and MAML1 proteins. PMID: 21124806
    21. SUMOylation of MAML1 is a mechanism for repressing MAML1 activity by influencing its interaction with HDAC7 PMID: 20203086
    22. Studies indicate that MAML1 functions as a coactivator for the tumor suppressor p53, MEF2C, beta-catenin and Notch signaling. PMID: 19751190
    23. Data support a model in which Notch-1 can activate the transcription of ERalpha-target genes via IKKalpha-dependent cooperative chromatin recruitment of Notch-CSL-MAML1 and ERalpha, which promotes the recruitment of p300. PMID: 19838210
    24. Mastermind mediates chromatin-specific transcription and turnover of the Notch enhancer complex PMID: 12050117
    25. requirement for cooperative assembly of the MAML1.ICN.CSL.DNA complex suggests that a primary function of ICN is to render CSL competent for MAML loading. PMID: 12644465
    26. MAML1 recruits CycC:CDK8 to phosphorylate the Notch ICD and coordinate activation with turnover. PMID: 15546612
    27. Results report the crystal structure of a Notch transcriptional activation complex containing the ankyrin domain of human Notch1, the transcription factor CSL on cognate DNA, and a polypeptide from the coactivator Mastermind-like-1 (MAML-1). PMID: 16530044
    28. MAML1 has a coactivator function for p53, independent of its function as a coactivator of Notch signaling pathway PMID: 17317671
    29. Maml1 participates in the Wnt signaling by modulating the beta-catenin/TCF activity. Maml1 is recruited by beta-catenin on the cyclin D1 and c-Myc promoters. Maml1 functions in the Wnt/beta-catenin pathway independently of Notch signaling. PMID: 17875709
    30. the RBP-Jkappa-associated domain of Notch increases the effective concentration of the ankyrin domain for its binding site on CSL, enabling docking of the ankyrin domain and subsequent recruitment of the Mastermind-like coactivator. PMID: 18155729

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  • 亚细胞定位：
    Nucleus speckle. Note=Nuclear, in a punctate manner.
  • 蛋白家族：
    Mastermind family
  • 组织特异性：
    Widely expressed with highest levels in heart, pancreas, peripheral blood leukocytes and spleen.
  • 数据库链接：

    HGNC: 13632

    OMIM: 605424

    KEGG: hsa:9794

    STRING: 9606.ENSP00000292599

    UniGene: Hs.631951