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MAN2C1 Antibody

  • 货号：
    CSB-PA878885LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry analysis of human appendix tissue using CSB-PA878885LA01HU at dilution of 1:100
    • Immunofluorescent analysis of Hela cells using CSB-PA878885LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) MAN2C1 Polyclonal antibody
  • Uniprot No.：
    Q9NTJ4
  • 基因名：
    MAN2C1
  • 别名：
    MAN2C1 antibody; MANA antibody; MANA1Alpha-mannosidase 2C1 antibody; EC 3.2.1.24 antibody; Alpha mannosidase 6A8B antibody; Alpha-D-mannoside mannohydrolase antibody; Mannosidase alpha class 2C member 1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Alpha-mannosidase 2C1 protein (746-969AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，MAN2C1 Antibody (CSB-PA878885LA01HU)，的标记方式是Non-conjugated。对于MAN2C1 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA878885LB01HU MAN2C1 Antibody, HRP conjugated ELISA
    FITC CSB-PA878885LC01HU MAN2C1 Antibody, FITC conjugated
    Biotin CSB-PA878885LD01HU MAN2C1 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Cleaves alpha 1,2-, alpha 1,3-, and alpha 1,6-linked mannose residues from glycoproteins. Involved in the degradation of free oligosaccharides in the cytoplasm.
  • 基因功能参考文献：
    1. MAN2C1 may contribute to the verbal difficulties observed in microduplications and to the intellectual disability of microdeletion syndromes PMID: 27355585
    2. Man2C1 has dual functions: one in glycan catabolism and another in apoptotic signaling. PMID: 23486476
    3. MAN2C1 binds PTEN thereby inhibiting its phosphatidylinositol 3,4,5 triphosphate phosphatase activity PMID: 21556061
    4. MAN2C1 methylation levels modify cumulative traumatic burden on risk of post traumatic stress disorder PMID: 21508515
    5. regulation of Man2C1 expression is essential for maintaining efficient protein N-glycosylation PMID: 20978011
    6. Reduced antibody response to BSA was observed in transgenic mice, suggesting that specific antibody response to tumor antigens might be suppressed by hMan2c1 transgene. PMID: 19572206
    7. plays an important role in preventing oncosis-like death in BJAB cells PMID: 12643454
    8. Results suggest that inhibition of alpha-mannosidase Man2c1 gene expression enhances adhesion of Jurkat T cells. PMID: 16721356
    9. Inhibition of MAN2C1 gene expression suppresses growth of esophageal carcinoma cells through mitotic arrest and apoptosis. PMID: 19018777

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  • 亚细胞定位：
    Cytoplasm.
  • 蛋白家族：
    Glycosyl hydrolase 38 family
  • 数据库链接：

    HGNC: 6827

    OMIM: 154580

    KEGG: hsa:4123

    STRING: 9606.ENSP00000267978

    UniGene: Hs.26232