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MAP3K10 Antibody

  • 货号：
    CSB-PA010199
  • 规格：
    ￥880
  • 其他：

产品详情

  • Uniprot No.：
    Q02779
  • 基因名：
    MAP3K10
  • 别名：
    M3K10_HUMAN antibody; MAP3K 10 antibody; Map3k10 antibody; MEKK10 antibody; Mitogen activated protein kinase kinase kinase 10 antibody; Mitogen-activated protein kinase kinase kinase 10 antibody; Mixed lineage kinase 2 antibody; MKN28 derived nonreceptor type serine/threonine kinase antibody; MKN28 kinase antibody; MLK 2 antibody; MST antibody; Protein kinase MST antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human MLK2.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    IHC, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:100-1:300
    ELISA 1:20000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Activates the JUN N-terminal pathway.
  • 基因功能参考文献：
    1. MST interaction with MOB1 is not essential for development and tissue growth control. PMID: 28947795
    2. We identified a direct target of miR-155 as MAP3K10 in osteosarcoma PMID: 28214207
    3. A novel and important role for MAP3K10 in the proliferation and chemoresistance of pancreatic ductal adenocarcinoma. PMID: 23178452
    4. This study showed that show that RUNX3 is a principal and evolutionarily conserved component of the MST pathway. PMID: 21678419
    5. Mechanism of MAP kinase activation by TNF requires Src-dependent activation of Vav, activation of Rac/Cdc42, and the engagement of the Rac/Cdc42 interaction site on MLK3. PMID: 21979919
    6. Mechanism of MAP kinase activation by TNF requires Src-dependent activation of Vav, activation of Rac/Cdc42, and the engagement of the Rac/Cdc42 interaction site on MLK2 and 3. PMID: 21979919
    7. Data show that miR-181b contributed to proliferation of AML cells by targeting MLK2. PMID: 20596961
    8. MLK2 has a role in vesicle formation and endosome recycling by binding to clathrin PMID: 12105200
    9. demonstrate Alien-MLK2 interaction and also show that MLK2 is able to phosphorylate Alien; Alien, DAX-1 and thyroid hormone receptor mediated transcriptional silencing is strongly enhanced in the presence of active MLK2 PMID: 15062575
    10. MLK2 and -3 are required for activation of JNK and p38 by ectopically expressed GCK PMID: 17584736
    11. Hippocalcin and MLK2 were colocalized in the halo of Lewy bodies in Parkinson disease patients, and neither protein was detected in normal pigmented neurons. PMID: 19332348
    12. Mixed lineage kinase phosphorylates transcription factor E47 and inhibits TrkB expression to link neuronal death and survival pathways PMID: 19801649

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  • 蛋白家族：
    Protein kinase superfamily, STE Ser/Thr protein kinase family, MAP kinase kinase kinase subfamily
  • 组织特异性：
    Expressed in brain and skeletal muscle.
  • 数据库链接：

    HGNC: 6849

    OMIM: 600137

    KEGG: hsa:4294

    STRING: 9606.ENSP00000253055

    UniGene: Hs.466743