Your Good Partner in Biology Research

  1. Home
  2. 抗体
  3. 多克隆抗体
  4. MAP3K6 Antibody

MAP3K6 Antibody

  • 货号：
    CSB-PA070217
  • 规格：
    ￥880
  • 其他：

产品详情

  • Uniprot No.：
    O95382
  • 基因名：
  • 别名：
    Apoptosis signal regulating kinase 2 antibody; Apoptosis signal-regulating kinase 2 antibody; ASK2 antibody; EC 2.7.11.25 antibody; M3K6_HUMAN antibody; MAP3K6 antibody; MAPKKK6 antibody; MEKK6 antibody; MGC125653 antibody; MGC20114 antibody; Mitogen-activated protein kinase kinase kinase 6 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human MEK Kinase-6.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    IHC, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:100-1:300
    ELISA 1:5000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Component of a protein kinase signal transduction cascade. Activates the JNK, but not ERK or p38 kinase pathways.
  • 基因功能参考文献：
    1. Data show that the MAPKKK6 ASK2, a modulator of MAPKKK5 ASK1 signaling, was essential for ASK1-dependent apoptosis, but not for inducing interferon-beta (IFNB) expression. PMID: 26243192
    2. MAP3K6 acts as a tumor suppressor, and studies showing the presence of somatic mutations in MAP3K6 in non-hereditary gastric cancers and gastric cancer cell lines, point towards MAP3K6 variants as a predisposing factor for familial gastric cancer PMID: 25340522
    3. Apoptosis signal-regulating kinase (ASK) 2 functions as a mitogen-activated protein kinase kinase kinase in a heteromeric complex with ASK1. PMID: 17210579
  • 蛋白家族：
    Protein kinase superfamily, STE Ser/Thr protein kinase family, MAP kinase kinase kinase subfamily
  • 数据库链接：

    HGNC: 6858

    OMIM: 604468

    KEGG: hsa:9064

    STRING: 9606.ENSP00000350195

    UniGene: Hs.194694