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MAP4K5 Antibody

  • 货号：
    CSB-PA013440DSR1HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human ovarian cancer using CSB-PA013440DSR1HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human prostate cancer using CSB-PA013440DSR1HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) MAP4K5 Polyclonal antibody
  • Uniprot No.：
    Q9Y4K4
  • 基因名：
    MAP4K5
  • 别名：
    MAP4K5 antibody; Mitogen-activated protein kinase kinase kinase kinase 5 antibody; EC 2.7.11.1 antibody; Kinase homologous to SPS1/STE20 antibody; KHS antibody; MAPK/ERK kinase kinase kinase 5 antibody; MEK kinase kinase 5 antibody; MEKKK 5 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Mitogen-activated protein kinase kinase kinase kinase 5 protein (300-480AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway.
  • 基因功能参考文献：
    1. MAP4K5 expression is decreased or lost in majority of pancreatic ductal adenocarcinoma. PMID: 27023625
    2. TNF signaling leads to oligomerization, ubiquitination, and activation of GCKR and activation of the SAPK pathway in a manner that depends upon TRAF2 polyubiquitination and oligomerization and Ubc13 function PMID: 12591926
    3. The -822G/A polymorphism in the promoter region of the MAP4K5 gene is associated with reduced risk of type 2 diabetes in Han Chinese from Shanghai. PMID: 16699725
  • 亚细胞定位：
    Cytoplasm.
  • 蛋白家族：
    Protein kinase superfamily, STE Ser/Thr protein kinase family, STE20 subfamily
  • 组织特异性：
    Ubiquitously expressed in all tissues examined, with high levels in the ovary, testis and prostate.
  • 数据库链接：

    HGNC: 6867

    OMIM: 604923

    KEGG: hsa:11183

    STRING: 9606.ENSP00000013125

    UniGene: Hs.130491