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MARCO Antibody

  • 货号：
    CSB-PA880072ESR2HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: MARCO antibody at 1.97µg/ml + Jurkat whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 53, 44 kDa
      Observed band size: 53 kDa
    • Immunohistochemistry of paraffin-embedded human lung tissue using CSB-PA880072ESR2HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human lung cancer using CSB-PA880072ESR2HU at dilution of 1:100
  • 其他：

产品详情

  • 产品描述：

    The MARCO antibody was inducibly expressed in a rabbit and the immunogen is the recombinant human MARCO protein (421-520aa). It was purified through antigen affinity chromatography.

    The MARCO polyclonal antibody has been validated for its specificity in ELISA, WB, and IHC applications. It can be used for the detection and investigation of human MARCO protein expression in different experiments. MARCO, a scavenger receptor expressed by macrophages and dendritic cells, mainly recognizes and binds to PAMPs thus triggering the immune response resulting in the phagocytosis and destruction of the invading microorganisms by the immune cells.

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) MARCO Polyclonal antibody
  • Uniprot No.：
    Q9UEW3
  • 基因名：
    MARCO
  • 别名：
    AI323439 antibody; Ly112 antibody; Macrophage receptor MARCO antibody; Macrophage receptor with collagenous structure antibody; Marco antibody; MARCO_HUMAN antibody; SCARA2 antibody; Scavenger receptor class A member 2 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Macrophage receptor MARCO protein (421-520AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Pattern recognition receptor (PRR) which binds Gram-positive and Gram-negative bacteria. Also plays a role in binding of unopsonized particles by alveolar macrophages. Binds to the secretoglobin SCGB3A2.
  • 基因功能参考文献：
    1. the absence of MARCO does not interfere with the efficiency of HSV-1 entry and that the inhibitory effect on viral adsorption by poly(I), a ligand of MARCO, is independent of MARCO. PMID: 29769337
    2. High surface expression of SR-A6 facilitates HAdV-C5 infection. PMID: 29522575
    3. These data suggest the SRCR domain of MARCO is the key domain in modulating ligand binding, enhancing downstream pro-inflammatory signaling and MARCO-mediated cellular adhesion. PMID: 26888252
    4. Expression of MARCO declined progressively as hepatocellular carcinoma condition is aggravated. PMID: 27806438
    5. MARCO single nucleotide polymorphisms rs12998782 increases risk to pulmonary tuberculosis in a Chinese Han population. PMID: 28693442
    6. CD36 and MARCO are associated with the susceptibility of Chinese Han females to carotid atherosclerosis. Menopausal status may affect the association between gene polymorphisms and carotid atherosclerosis in the female Chinese Han population. PMID: 28866086
    7. Increasing MARCO expression by targeting Nrf2 signaling or the Akt-TFEB-MARCO pathway are promising strategies to improve bacterial clearance and survival in postinfluenza bacterial pneumonia. PMID: 28408365
    8. results suggest that MARCO polymorphisms may regulate phagocytosis of M. tuberculosis and susceptibility and severity of pulmonary tuberculosis PMID: 27853145
    9. this paper shows that key gene of intermediate proinflammatory monocytes, such as MARCO, is expressed three- to fourfold more in juvenile idiopathic arthritis-enthesitis-related arthritis PMID: 27706807
    10. this study shows that MARCO modulates inflammatory responses against Cryptococcus neoformans infection PMID: 28298522
    11. this translational investigation identified gene candidates, including Marco, for host susceptibility to multiple phenotypes of RSV disease in mice that closely mimic human disease, and a polymorphism in human MARCO associated with increased risk of RSV disease severity in infants. PMID: 27554839
    12. Identifying N-linked glycan moiety and motifs in the cysteine-rich domain critical for N-glycosylation and intracellular trafficking of SR-AI and MARCO. PMID: 26892079
    13. identified as a disease-associated molecule in IgG4-related disease by DNA microarray PMID: 26886650
    14. None of the nonsynonymous variants discovered by resequencing of the structurally similar MARCO were associated with lung function or risk of COPD. PMID: 25186548
    15. Vaccinia virus bound directly to MARCO, and overexpression of MARCO increased susceptibility to vaccinia infection. PMID: 25089661
    16. Significant associations of four SNPs and haplotypes with antibody response to cholera vaccine in three genes, MARCO, TNFAIP3 and CXCL12. PMID: 23249958
    17. herpes simplex virus type 1 binds to MARCO to enhance its capacity for disease. PMID: 23739639
    18. We identified 9 non-synonymous variants in the MARCO gene and showed that these variants are not major risk factors for COPD or lung infection. H101Q heterozygotes had increased sepsis risk. PMID: 23154236
    19. Polymorphisms within the human class A scavenger receptor MARCO correlate with susceptibility/resistance to tuberculosis in a Gambian population. PMID: 23617307
    20. In this review, we showed that SR-A and MARCO trigger intracellular signaling, modulating pro-inflammatory and microbicidal activities of macrophages. PMID: 22470185
    21. This review demonstrated that class A SR and MARCO are major pattern recognition receptors mediating opsonin-independent phagocytosis. PMID: 22470186
    22. genetic variants in MARCO gene were associated with pulmonary tuberculosis susceptibility in Chinese Han population PMID: 21886847
    23. These results demonstrate that the S. mutans lipoprotein PpiA contributes to suppression of MARCO-mediated phagocytosis of this bacterium by macrophages. PMID: 21986627
    24. Data suggest that bacteria induce glial cell activation and rCRAMP expression via FPRL1 and MARCO, and these receptors contribute to the host defence against infection. PMID: 21299846
    25. MARCO is an important phagocytic receptor used by human and mouse macrophages to clear C. sordellii from the infected uterus PMID: 20810988
    26. An arginine-rich segment in domain V of MARCO and particularly its RXR motifs play a critical role in high-affinity bacterial binding. PMID: 11820786
    27. characterization of a MARCO protein domain involved in binding to bacteria PMID: 12097327
    28. Northern blot and in situ hybridization experiments indicate that MARCO is expressed by alveolar macrophages in the lung; retroviral vector-mediated expression cloning determines that MARCO is a receptor for UGRP1. PMID: 12847263
    29. a dominant role for MARCO in the human AM defense against inhaled particles and pathogens. PMID: 16237101
    30. Expansion of small sputum macrophages in cystic fibrosis shows a failure to express MARCO and CD206. PMID: 19403625

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  • 亚细胞定位：
    Cell membrane; Single-pass type II membrane protein.
  • 组织特异性：
    Expressed in alveolar macrophages (at protein level). Detected in macrophages from various tissues including thymus, kidney, Kupffer cells of liver, and spleen.
  • 数据库链接：

    HGNC: 6895

    OMIM: 604870

    KEGG: hsa:8685

    STRING: 9606.ENSP00000318916

    UniGene: Hs.67726