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  4. MARK3 Antibody

MARK3 Antibody

  • 货号：
    CSB-PA001817
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of 293 cells using C-TAK1 Polyclonal Antibody
    • Western Blot analysis of MOUSE-BRAIN cells using C-TAK1 Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    P27448
  • 基因名：
  • 别名：
    C-TAK1 antibody; Cdc25C associated protein kinase 1 antibody; Cdc25C-associated protein kinase 1 antibody; cTAK1 antibody; ELKL motif kinase 2 antibody; EMK-2 antibody; Emk2 antibody; ETK 1 antibody; KIAA4230 antibody; KP78 antibody; MAP microtubule affinity regulating kinase 3 antibody; MAP/microtubule affinity-regulating kinase 3 antibody; Mark3 antibody; MARK3_HUMAN antibody; Par 1a antibody; PAR1A antibody; Protein kinase STK10 antibody; Ser/Thr protein kinase PAR-1 antibody; Serine threonine protein kinase p78 antibody; Serine/threonine-protein kinase p78 antibody; SerThr protein kinase PAR 1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from the N-terminal region of Human C-TAK1.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, IHC, IF, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    IF 1:200-1:1000
    ELISA 1:40000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Serine/threonine-protein kinase. Involved in the specific phosphorylation of microtubule-associated proteins for MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TAU. Phosphorylates CDC25C on 'Ser-216'. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus. Negatively regulates the Hippo signaling pathway and antagonizes the phosphorylation of LATS1. Cooperates with DLG5 to inhibit the kinase activity of STK3/MST2 toward LATS1.
  • 基因功能参考文献：
    1. s identified a regulatory switch controlled by MARK3 that couples microtubules to the actin cytoskeleton to establish epithelial cell polarity through ARHGEF2. PMID: 29089450
    2. findings indicate that brain PP-1I associates with and is regulated by the associated protein kinases C-TAK1 and PFTK1 PMID: 25028520
    3. We have shown that serum ALP levels modified the association of MARK3 with bone mineral density in osetoporosis for Chinese patients. PMID: 23894155
    4. interaction between Mitf and C-TAK1 was demonstrated. PMID: 20214879
    5. results show that LKB1 can direct the phosphorylation of the serine-threonine kinase PAR1A PMID: 12879020
    6. identify sequence motifs required for stable C-TAK1 association and substrate phosphorylation PMID: 12941695
    7. The C-TAK1/p78 constitutively associates with and phosphorylates KSR1 generating a 14-3-3 binding site. PMID: 15182702
    8. Data show that the protein kinase Cdc25 C-associated kinase 1 (C-TAK1) is a binding partner and a substrate of Pim-1, and suggest a role for Pim-1 as a positive regulator at the G(2)/M transition of the cell cycle. PMID: 15319445
    9. 14-3-3 binding to MARK3 is dependent on phosphorylation. PMID: 16968750
    10. Class IIa histone deacetylases (HDACs) are subjected to signal-independent nuclear export that relies on their constitutive phosphorylation. EMK and C-TAK1, are identified as regulators of this process. PMID: 16980613
    11. identify a molecular mechanism through which the hMARK3 UBA domain has evolved to bind the kinase domain PMID: 17726107
    12. occurrence of an unusual TG 3' splice site in intron 3 PMID: 17672918

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  • 亚细胞定位：
    Cell membrane; Peripheral membrane protein. Cell projection, dendrite. Cytoplasm.
  • 蛋白家族：
    Protein kinase superfamily, CAMK Ser/Thr protein kinase family, SNF1 subfamily
  • 组织特异性：
    Ubiquitous.
  • 数据库链接：

    HGNC: 6897

    OMIM: 602678

    KEGG: hsa:4140

    STRING: 9606.ENSP00000411397

    UniGene: Hs.35828