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  4. MARVELD1 Antibody

MARVELD1 Antibody

  • 中文名称：
    MARVELD1兔多克隆抗体
  • 货号：
    CSB-PA106910
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using CSB-PA106910(MARVELD1 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using CSB-PA106910(MARVELD1 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane: Mouse heart tissue, Primary antibody: CSB-PA106910(MARVELD1 Antibody) at dilution 1/300, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 minutes
  • 其他：

产品详情

  • Uniprot No.：
    Q9BSK0
  • 基因名：
    MARVELD1
  • 别名：
    MARVELD1; MRVLDC1; MARVEL domain-containing protein 1
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Synthetic peptide of Human MARVELD1
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    WB 1:200-1:1000
    IHC 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Microtubule-associated protein that exhibits cell cycle-dependent localization and can inhibit cell proliferation and migration.
  • 基因功能参考文献：
    1. MARVELD1 substantially inhibits nonsense-mediated RNA decay by decreasing the pioneer round of translation but not steady-state translation, and is an important component of the molecular machinery containing UPF1 and Y14. MARVELD1 promotes the dissociation of SMG1 from UPF1, resulting in the repression of serine phosphorylation of UPF1, and subsequently blocks the recruitment of SMG5. PMID: 23826386
    2. Study demonstrates that MARVELD1-mediated balance of integrin beta1 and beta4 regulates cell surface ultrastructure and epithelial-mesenchymal transition phenotype of non-small cell lung cancer (NSCLC). PMID: 26509557
    3. MARVELD1 silencing is an appealing diagnostic biomarker for lung cancer. PMID: 25520033
    4. Importin-beta1 mediates the non-classical nucleocytoplasmic transport of MARVELD1. PMID: 26107903
    5. MARVELD1 plays a role in pre-mRNA processing of integrin beta1. PMID: 24055813
    6. Our findings suggest that MARVELD1 is a tumor suppressor by negatively regulating proliferation, tumor growth and chemosensitivity of HCC cells via increasing p53 and p16 in vitro and in vivo. PMID: 22320884
    7. MARVELD1 protein is located in nucleus instead of cell membrane in several different tumors, in males and in females. PMID: 19364627

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein. Cytoplasm, cytoskeleton. Nucleus.
  • 组织特异性：
    Widely expressed in normal tissues. Down-regulated in multiple primary tumors.
  • 数据库链接：

    HGNC: 28674

    KEGG: hsa:83742

    STRING: 9606.ENSP00000441365

    UniGene: Hs.744073