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MAST2 Antibody

  • 货号：
    CSB-PA003196
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of 293 cells using MAST205 Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    Q6P0Q8
  • 基因名：
    MAST2
  • 别名：
    EC 2.7.11.1 3 antibody; FLJ39200 antibody; KIAA0807 antibody; MAST 2 antibody; MAST 205 antibody; Mast2 antibody; MAST2_HUMAN antibody; Microtubule associated serine/threonine kinase 2 antibody; Microtubule associated testis specific serine/threonine protein kinase antibody; Microtubule-associated serine/threonine-protein kinase 2 antibody; MTSSK antibody; OTTHUMP00000009697 2 antibody; OTTHUMP00000046616 antibody; RP4 533D7.1 antibody; RP4-533D7.1 2 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human MAST205.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, IHC, IF, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    IF 1:200-1:1000
    ELISA 1:40000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins. Functions in a multi-protein complex in spermatid maturation. Regulates lipopolysaccharide-induced IL-12 synthesis in macrophages by forming a complex with TRAF6, resulting in the inhibition of TRAF6 NF-kappa-B activation.
  • 基因功能参考文献：
    1. we observed 3 case-specific duplications of the autosomal gene MAST2, and in a replication phase we found another 11 duplications PMID: 26203179
    2. Viral and PTEN peptide interactions to MAST2-PDZ occur via a unique kinetic step which involves both canonical C-terminal PBM binding and N-terminal anchoring. PMID: 25942057
    3. MAST2 gene rearrangements occur in invasive breast carcinoma. PMID: 24140425
    4. MAST205 plays an important role in regulating CFTR expression and function PMID: 23504457
    5. The MAST2 sequence at the 5' end of SVA(F1) acts as a positive transcriptional regulator in human germ cells. PMID: 22609064
    6. Recruitment of a MAST2 CpG island was most likely beneficial to the hybrid retrotransposons because it could significantly increase retrotransposition frequency. PMID: 19961423
    7. Studies report the identification of a new subfamily of SVA, which apparently formed after an alternative splicing event where the first exon of the MAST2 gene spliced into an intronic SVA and subsequently retrotransposed. PMID: 19635844

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  • 亚细胞定位：
    Cytoplasm, cytoskeleton. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Recruited to the sub-membranous area on interaction with CDHR2.
  • 蛋白家族：
    Protein kinase superfamily, AGC Ser/Thr protein kinase family
  • 组织特异性：
    Abundant in the testis.
  • 数据库链接：

    HGNC: 19035

    OMIM: 612257

    KEGG: hsa:23139

    STRING: 9606.ENSP00000354671

    UniGene: Hs.319481