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MBNL3 Antibody

  • 货号：
    CSB-PA567465
  • 规格：
    ￥1100
  • 图片：
    • The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA567465(MBNL3 Antibody) at dilution 1/20. (Original magnification: ×200)
    • The image is immunohistochemistry of paraffin-embedded Human brain tissue using CSB-PA567465(MBNL3 Antibody) at dilution 1/20. (Original magnification: ×200)
  • 其他：

产品详情

  • Uniprot No.：
    Q9NUK0
  • 基因名：
    MBNL3
  • 别名：
    A530038J18Rik antibody; AI661274 antibody; CHCR antibody; Cys3His CCG1 required protein antibody; Cys3His CCG1-required protein antibody; E430034C16Rik antibody; MBLX antibody; MBLX39 antibody; MBNL 3 antibody; Mbnl3 antibody; MBNL3_HUMAN antibody; MBXL antibody; Muscleblind like 3 antibody; Muscleblind like protein 3 antibody; Muscleblind like splicing regulator 3 antibody; Muscleblind like X linked protein antibody; Muscleblind-like protein 3 antibody; Muscleblind-like X-linked protein antibody; OTTMUSP00000019072 antibody; OTTMUSP00000019073 antibody; OTTMUSP00000019074 antibody; Protein HCHCR antibody; RP23-98P13.1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Fusion protein of Human MBNL3
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    IHC 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Mediates pre-mRNA alternative splicing regulation. Acts either as activator or repressor of splicing on specific pre-mRNA targets. Inhibits cardiac troponin-T (TNNT2) pre-mRNA exon inclusion but induces insulin receptor (IR) pre-mRNA exon inclusion in muscle. Antagonizes the alternative splicing activity pattern of CELF proteins. May play a role in myotonic dystrophy pathophysiology (DM). Could inhibit terminal muscle differentiation, acting at approximately the time of myogenin induction.
  • 基因功能参考文献：
    1. The MBNL3 splicing factor promotes hepatocellular carcinoma by increasing pacillin expression through the alternative splicing of lncRNA-PXN-AS1. PMID: 28553938
    2. results suggest that CHCR is an inhibitor of myogenesis PMID: 12297108
    3. MBNL proteins promote opposite splicing patterns for cardiac troponin T and insulin receptor alternative exons PMID: 15257297
    4. We exclude MBNL3 as the causative gene in this family. PMID: 17102799
    5. MBNL3 was not found in human samples. PMID: 19095965

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  • 亚细胞定位：
    Nucleus. Cytoplasm. Note=Greater concentration in the nucleus. In both DM1 and DM2 patients, colocalizes with nuclear foci of retained expanded-repeat transcripts.
  • 蛋白家族：
    Muscleblind family
  • 组织特异性：
    Highly expressed in the placenta.
  • 数据库链接：

    HGNC: 20564

    OMIM: 300413

    KEGG: hsa:55796

    STRING: 9606.ENSP00000359890

    UniGene: Hs.105134