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  4. MCM8 Antibody

MCM8 Antibody

  • 货号：
    CSB-PA013598GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q9UJA3
  • 基因名：
    MCM8
  • 别名：
    C20orf154 antibody; dJ967N21.5 antibody; DNA helicase MCM8 antibody; DNA replication licensing factor MCM8 antibody; MCM8 antibody; MCM8_HUMAN antibody; MGC119522 antibody; MGC119523 antibody; MGC12866 antibody; MGC4816 antibody; Minichromosome maintenance 8 antibody; Minichromosome maintenance complex component 8 antibody; REC antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human MCM8
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Component of the MCM8-MCM9 complex, a complex involved in the repair of double-stranded DNA breaks (DBSs) and DNA interstrand cross-links (ICLs) by homologous recombination (HR). Required for DNA resection by the MRE11-RAD50-NBN/NBS1 (MRN) complex by recruiting the MRN complex to the repair site and by promoting the complex nuclease activity. Probably by regulating the localization of the MNR complex, indirectly regulates the recruitment of downstream effector RAD51 to DNA damage sites including DBSs and ICLs. The MCM8-MCM9 complex is dispensable for DNA replication and S phase progression. However, may play a non-essential for DNA replication: may be involved in the activation of the prereplicative complex (pre-RC) during G(1) phase by recruiting CDC6 to the origin recognition complex (ORC). Probably by regulating HR, plays a key role during gametogenesis. Stabilizes MCM9 protein.
  • 基因功能参考文献：
    1. Additional support to the view that MCM8 mutations are involved in the primary ovarian insufficiency phenotype. PMID: 28863940
    2. stalled replication forks can be restarted in S phase via homologous recombination using MCM8-9 as an alternative replicative helicase. PMID: 28487407
    3. study showed that copy number increase and overexpression of MCM8 may play critical roles in human cancer development. PMID: 28481876
    4. Significant number of potentially damaging and novel variants in MCM8 in primary ovarian insufficiency; multiallelic association with variants in DDR and MCM8-MCM9 interactome genes. PMID: 27802094
    5. Novel mutations p. H317L and p. H601R in the MCM8 gene are potentially causative for primary ovarian insufficiency by dysfunctional DNA repair. PMID: 27573988
    6. Suggest role for MCM8 in the pathogenesis of chronic myelogenous leukemia. PMID: 26823731
    7. MCM8, a component of the pre-replication complex, is crucial for gonadal development and maintenance in humans-both males and females. These PMID: 25873734
    8. An autosomal recessive ovarian failure disorder caused by an MCM8 mutation that manifests with endocrine dysfunction and genomic instability. PMID: 25437880
    9. Chromatin immunoprecipitation analysis using human DR-GFP cells demonstrated that MCM8 and MCM9 proteins are rapidly recruited to DNA damage sites and promote RAD51 recruitment. PMID: 23401855
    10. Single Nucleotide Polymorphism in MCM8 is associated with ovarian follicle number and menopause. PMID: 22696150
    11. Single nucleotide polymorphism in MCM8 is associated with menopause and the length of reproductive lifespan. PMID: 22131368
    12. The MCM8 gene is located contrapodal to GCD10 at chromosome band 20p12.3-13. PMID: 12771218
    13. MCM8 is a crucial component of the pre-RC and that the interaction between hMCM8 and hcdc6 is required for pre-RC assembly. PMID: 15684404
    14. We find that MCM8, like MCM7, colocalizes on a specific DNA segment of the c-MYC replication initiation zone (c-MYC replicator) of DNA replications together with Cdc6 and cdk2, but differs with MCM7 in spatial relation to RPA70 during S phase. PMID: 18072282

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  • 相关疾病：
    Premature ovarian failure 10 (POF10)
  • 亚细胞定位：
    Nucleus. Chromosome.
  • 蛋白家族：
    MCM family
  • 组织特异性：
    Highest levels in placenta, lung and pancreas. Low levels in skeletal muscle and kidney. Expressed in various tumors with highest levels in colon and lung cancers.
  • 数据库链接：

    HGNC: 16147

    OMIM: 608187

    KEGG: hsa:84515

    STRING: 9606.ENSP00000368174

    UniGene: Hs.597484