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MDH2 Antibody

  • 货号：
    CSB-PA013623ESR1HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: MDH2 antibody at 3µg/ml
      Lane 1: 293T whole cell lysate
      Lane 2: K562 whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 36, 31 kDa
      Observed band size: 36 kDa
    • Immunohistochemistry of paraffin-embedded human lung cancer using CSB-PA013623ESR1HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) MDH2 Polyclonal antibody
  • Uniprot No.：
    P40926
  • 基因名：
    MDH2
  • 别名：
    M MDH antibody; Malate dehydrogenase 2; NAD (mitochondrial) antibody; Malate dehydrogenase antibody; Malate dehydrogenase; mitochondrial antibody; MDH antibody; mdh2 antibody; MDHM_HUMAN antibody; MGC:3559 antibody; mitochondrial antibody; Mitochondrial malate dehydrogenase 2; NAD antibody; Mor 1 antibody; MOR1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Malate dehydrogenase, mitochondrial protein (59-338AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 基因功能参考文献：
    1. these data suggest that MDH2, functioning as an RNA-binding protein, is involved in the posttranscriptional downregulation of SCN1A expression under seizure condition. PMID: 28433711
    2. loss-of-function mutations in MDH2 are also associated with severe neurological clinical presentations in children PMID: 27989324
    3. Data indicate that acetyl-CoA acetyltransferase (ACAT1) and malate dehydrogenase (MDH2) are involved in various drug-resistance-forming mechanisms. PMID: 25639359
    4. Segregation of the mutation with disease and absence of MDH2 in mutated tumors revealed MDH2 as a novel pheochromocytoma/paraganglioma susceptibility gene. PMID: 25766404
    5. L-2-hydroxyglutarate accumulates as a result of a deficiency in FAD-linked L-2-hydroxyglutarate dehydrogenase. mitochondrial L-malate dehydrogenase is responsible for the excretion of L-2-hydroxyglutarate in this condition. PMID: 17603759

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  • 相关疾病：
    Epileptic encephalopathy, early infantile, 51 (EIEE51)
  • 亚细胞定位：
    Mitochondrion matrix.
  • 蛋白家族：
    LDH/MDH superfamily, MDH type 1 family
  • 数据库链接：

    HGNC: 6971

    OMIM: 154100

    KEGG: hsa:4191

    STRING: 9606.ENSP00000327070

    UniGene: Hs.520967