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MED23 Antibody

  • 货号：
    CSB-PA936886
  • 规格：
    ￥2024
  • 图片：
    • Western blot analysis of extracts from A549 cells, using MED23 antiobdy.
    • Immunohistochemistry analysis of paraffin-embedded human colon carcinoma tissue, using MED23 antibody.
    • Immunofluorescence analysis of A549 cells, using MED23 antibody.
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) MED23 Polyclonal antibody
  • Uniprot No.：
    Q9ULK4
  • 基因名：
    MED23
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Synthesized peptide derived from internal of Human MED23.
  • 免疫原种属：
    Homo sapiens (Human)
  • 克隆类型：
    Polyclonal
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC,IF
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:3000
    IHC 1:50-1:100
    IF 1:100-1:500
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Required for transcriptional activation subsequent to the assembly of the pre-initiation complex. Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors. Required for transcriptional activation by adenovirus E1A protein. Required for ELK1-dependent transcriptional activation in response to activated Ras signaling.
  • 基因功能参考文献：
    1. MED23 adopts an arch-shaped conformation, with an N-terminal domain (Nter) protruding from a large core region. PMID: 30140054
    2. This is the first patient with documented refractory epilepsy caused by a novel homozygous pathogenic variant in MED23 expanding the phenotypic spectrum. Identification of the underlying genetic defect in MED23 sheds light on the possible mechanism of complete response to the ketogenic diet in this child. PMID: 27311965
    3. a 7-gene signature was identified which correctly predicted the primary prefibrotic myelofibrosis group with a sensitivity of 100% and a specificity of 89%. The 7 genes included MPO, CEACAM8, CRISP3, MS4A3, CEACAM6, HEMGN, and MMP8 PMID: 27579896
    4. Higher l-arginine was associated with higher risk of Ischemic heart disease (odds ratio and of myocardial infarction, based on 2 SNPs from MED23. PMID: 27914500
    5. MED23-associated intellectual disability has been found in two brothers from a non-consanguineous family. PMID: 25845469
    6. MED23 plays an important role in hepatocarcinogenesis, and it may be a novel target for HCC therapy. PMID: 25684393
    7. Upregulation of mediator MED23 in non-small-cell lung cancer promotes the growth, migration, and metastasis of cancer cells. PMID: 25273169
    8. Mediator MED23 regulates basal transcription in vivo via an interaction with P-TEFb. PMID: 23340209
    9. Data show that Med23 RNAi specifically inhibits the proliferation and tumorigenicity of lung cancer cells with hyperactive Ras activity. PMID: 22988093
    10. missense mutation (p. R617Q) in MED23 that cosegregates with nonsyndromic autosomal recessive intellectual disability; mutation impaired response of JUN and FOS to mitogens by altering interaction between enhancer-bound transcription factors and Mediator PMID: 21868677
    11. DRIP130 regulates HER2 expression by binding to ESX PMID: 12242338
    12. loss of DRIP-130 expression, as a result of the gross loss of human chromosome 6q16.3-q23, provokes increased tumor metastasis PMID: 16964286
    13. Sur2(CRSP3) is required for activation by Adenovirus E1A CR3 activation domain and is required for MAPK-mediated activation of Elk-1. PMID: 11934987

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  • 相关疾病：
    Mental retardation, autosomal recessive 18 (MRT18)
  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    Mediator complex subunit 23 family
  • 数据库链接：

    HGNC: 2372

    OMIM: 605042

    KEGG: hsa:9439

    STRING: 9606.ENSP00000357047

    UniGene: Hs.29679