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  4. MED27 Antibody

MED27 Antibody

  • 货号：
    CSB-PA080009
  • 规格：
    ￥880
  • 其他：

产品详情

  • Uniprot No.：
    Q6P2C8
  • 基因名：
    MED27
  • 别名：
    Cofactor required for Sp1 transcriptional activation subunit 8 (34kD) antibody; Cofactor required for Sp1 transcriptional activation subunit 8 34kDa antibody; Cofactor required for Sp1 transcriptional activation subunit 8 antibody; CRAP 34 antibody; CRAP34 antibody; CRSP 34 antibody; CRSP 8 antibody; CRSP complex subunit 8 antibody; CRSP34 antibody; CRSP8 antibody; MED 27 antibody; Med27 antibody; MED27_HUMAN antibody; Mediator complex subunit 27 antibody; Mediator of RNA polymerase II transcription subunit 27 antibody; MGC11274 antibody; P37 TRAP/SMCC/PC2 subunit antibody; Transcriptional coactivator CRSP34 antibody; TRAP 37 antibody; TRAP37 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human CRSP34.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:10000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
  • 基因功能参考文献：
    1. The findings of the present study may aid in the clarification of the function of miR18a, particularly as regards its role in the regulation of Osteosarcoma (OS)cell apoptosis, and indicate that MED27 may be a potential novel therapeutic target in the treatment of OS. PMID: 29693135
    2. MED27 promotes melanoma growth by targeting AKT/MAPK and NF-kappaB/iNOS signaling pathways. PMID: 26797421
  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    Mediator complex subunit 27 family
  • 数据库链接：

    HGNC: 2377

    OMIM: 605044

    KEGG: hsa:9442

    STRING: 9606.ENSP00000292035

    UniGene: Hs.374262