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  4. MED28 Antibody

MED28 Antibody

  • 货号：
    CSB-PA922141
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using CSB-PA922141(MED28 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using CSB-PA922141(MED28 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: ×200)
    • Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane: Human placenta tissue, Primary antibody: CSB-PA922141(MED28 Antibody) at dilution 1/400 dilution, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 30 seconds
  • 其他：

产品详情

  • Uniprot No.：
    Q9H204
  • 基因名：
    MED28
  • 别名：
    EG1 antibody; Endothelial-derived protein 1 antibody; FKSG20 antibody; Magicin antibody; med28 antibody; MED28_HUMAN antibody; Mediator complex subunit 28 antibody; Mediator of RNA polymerase II transcription subunit 28 antibody; Merlin and Grb2-interacting cytoskeletal protein antibody; Tumor angiogenesis marker EG-1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Full length fusion protein
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    WB 1:500-1:2000
    IHC 1:25-1:100
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. May be part of a complex containing NF2/merlin that participates in cellular signaling to the actin cytoskeleton downstream of tyrosine kinase signaling pathways.
  • 基因功能参考文献：
    1. MED28 modulates the development of epithelial-mesenchymal transition through NFkappaB in human breast cancer cells. PMID: 27662245
    2. All trans-retinoic acid can reverse the suppressive effect of MED28 on HBP1 and E-cadherin and inactivate the Wnt/beta-catenin pathway in colorectal cancer, suggesting a protective effect of ATRA against colorectal cancer. PMID: 26660958
    3. This paper describes a link between Med23 and IFN-lambda3, provides evidence for the crucial role of IFN-lambda in HSV-1 immune control. PMID: 23950709
    4. These data indicate that MED28 regulates cellular migration in a MEK1-dependent manner in human breast cancer cells, reinforcing the important cellular roles of MED28. PMID: 22495818
    5. High MED28 is associated with breast cancer. PMID: 20584319
    6. demonstrate an interaction between Grb2 and magicin. In addition, merlin is capable of forming a ternary complex with magicin and Grb2 PMID: 15467741
    7. EG-1 is a positive stimulator of cellular proliferation, and may possibly be involved in signaling pathways involving Src and MAPK activation. PMID: 16024617
    8. May serve as a multi-faceted adaptor/scaffold to relay cellular signaling to the cytoskeleton and from the cytoskeleton to the nucleus. PMID: 16899217
    9. EG-1 may be involved in signaling pathways including c-Src activation. PMID: 16964398
    10. EG-1 has a role in breast tumor growth PMID: 17568184
    11. Study reports that down-regulation of human Med28 expression in NIH3T3 cells results in a significant induction of several genes associated with smooth muscle cell (SMC)differentiation; conversely, overexpression of MED28 represses SMC gene expression. PMID: 17848560

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  • 亚细胞定位：
    Nucleus. Cytoplasm. Membrane; Peripheral membrane protein. Note=According to PubMed:15467741, it is cytoplasmic and mainly membrane-associated.
  • 蛋白家族：
    Mediator complex subunit 28 family
  • 组织特异性：
    Widely expressed. Highly expressed in vascular tissues such as placenta, testis and liver.
  • 数据库链接：

    HGNC: 24628

    OMIM: 610311

    KEGG: hsa:80306

    STRING: 9606.ENSP00000237380

    UniGene: Hs.731966