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MED8 Antibody

  • 中文名称：
    MED8兔多克隆抗体
  • 货号：
    CSB-PA006810
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of JK cells using Med8 Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    Q96G25
  • 基因名：
    MED8
  • 别名：
    Activator recruited cofactor 32 kDa component antibody; Activator-recruited cofactor 32 kDa component antibody; ARC32 antibody; med8 antibody; MED8_HUMAN antibody; Mediator complex subunit 8 antibody; Mediator of RNA polymerase II transcription subunit 8 antibody; Mediator of RNA polymerase II transcription subunit 8 homolog antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human Med8.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:5000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. May play a role as a target recruitment subunit in E3 ubiquitin-protein ligase complexes and thus in ubiquitination and subsequent proteasomal degradation of target proteins.
  • 基因功能参考文献：
    1. mammalian mediator subunit mMED8 is an elongin BC-interacting protein that can assemble with Cul2 and Rbx1 reconstitute a ubiquitin ligase (Ubc5; E2 ubiquitin-conjugating enzyme Ubc5) PMID: 12149480
    2. ability to inhibit both host transcription and the interferon response is linked to interaction of NSs with the MED8 component of Mediator, a protein complex necessary for mRNA production PMID: 16973571
  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    Mediator complex subunit 8 family
  • 数据库链接：

    HGNC: 19971

    OMIM: 607956

    KEGG: hsa:112950

    STRING: 9606.ENSP00000290663

    UniGene: Hs.301756