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MEF2C Antibody

  • 货号：
    CSB-PA010171
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of 293T cells using MEF-2C Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    Q06413
  • 基因名：
  • 别名：
    C5DELq14.3 antibody; DEL5q14.3 antibody; MADS box transcription enhancer factor 2 polypeptide C (myocyte enhancer factor 2C) antibody; MADS box transcription enhancer factor 2, polypeptide C antibody; MEF2C antibody; MEF2C_HUMAN antibody; Myocyte enhancer factor 2C antibody; Myocyte specific enhancer factor 2C antibody; Myocyte-specific enhancer factor 2C antibody; OTTHUMP00000222409 antibody; Similar to MADS box transcription enhancer factor 2 polypeptide C antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Synthesized peptide derived from Human MEF-2C around the non-phosphorylation site of S396.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, IHC, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:40000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. Enhances transcriptional activation mediated by SOX18. Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. Crucial for normal neuronal development, distribution, and electrical activity in the neocortex. Necessary for proper development of megakaryocytes and platelets and for bone marrow B-lymphopoiesis. Required for B-cell survival and proliferation in response to BCR stimulation, efficient IgG1 antibody responses to T-cell-dependent antigens and for normal induction of germinal center B-cells. May also be involved in neurogenesis and in the development of cortical architecture. Isoforms that lack the repressor domain are more active than isoform 1.
  • 基因功能参考文献：
    1. This study indicates MEF2C as a new gene responsible for human dilated cardiomyopathy (DCM), which provides novel insight into the mechanism underpinning DCM, suggesting potential implications for development of innovative prophylactic and therapeutic strategies for DCM, the most prevalent form of primary myocardial disease. PMID: 28902616
    2. Overexpression of MEF2C decreased miR-448-induced VSMCs proliferation and migration. PMID: 28799067
    3. MEF2C mRNA expression levels in AD subjects are significantly lower than those in control subjects and are correlated with disease severity. PMID: 29112298
    4. The regulation mechanism of MIG6 and suggests potential implications for the therapeutic strategies of gefitinib resistance through inhibiting MEF2C in hepatic cancer cells. PMID: 29714661
    5. This study firstly associates MEF2C loss-of-function mutation with double outlet right ventricle in humans, which provides novel insight into the molecular pathogenesis of congenital heart diseases. PMID: 29468350
    6. Combined with automated 2D nano-scale chromatography, Accumulated ion monitoring achieved subattomolar limits of detection of endogenous proteins in complex biological proteomes. This allowed quantitation of absolute abundance of the human transcription factor MEF2C at approximately 100 molecules/cell, and determination of its phosphorylation stoichiometry from as little as 1 mug of extracts isolated from 10,000 human ... PMID: 28821601
    7. the mutation significantly diminished the synergistic activation between MEF2C and GATA4, another cardiac core transcription factor that has been causally linked to Congenital heart disease (CHD). PMID: 29104469
    8. MEF2C expression levels were significantly associated with or may even be predictive of the response to glucocorticoid treatment. PMID: 28482719
    9. MEF2C rs190982 polymorphism has a role in late-onset Alzheimer's disease in Han Chinese PMID: 27276684
    10. MEF2C mRNA level is up-regulated in both sporadic and SOD1 + ALS patients. PMID: 26921792
    11. a MEF2C and CEBPA correlation in CML disease progression PMID: 27297623
    12. Single nucleotide polymorphism in MEF2C gene is associated with major depressive disorder. PMID: 27479909
    13. we identified novel associations in WLS , ARHGAP1 , and 5' of MEF2C ( P- values < 8x10 - 5 ; false discovery rate (FDR) q-values < 0.01) that were much more strongly associated with BMD compared to the GWAS SNPs. PMID: 27616567
    14. Our analysis consistently identified significant sub-networks associated with the interacting transcription factors MEF2C and TWIST1, genes not previously associated with spontaneous preterm births , both of which regulate processes clearly relevant to birth timing. PMID: 27664809
    15. Key role for miR-214 in modulation of MEF2C-MYOCD-LMOD1 signaling. PMID: 27144530
    16. Endothelial Mef2c regulates the endothelial actin cytoskeleton and inhibits smooth muscle cell migration into the intima. PMID: 28473437
    17. The mRNA expressions of PPP3CB and MEF2C were significantly up-regulated, and CAMK1 and PPP3R1 were significantly down-regulated in mitral regurgitation(MR) patients compared to normal subjects. Moreover, MR patients had significantly increased mRNA levels of PPP3CB, MEF2C and PLCE1 compared to aortic valve disease patients PMID: 27907007
    18. Findings suggest that a single introduction of the three cardiomyogenic transcription factor (GATA4, cand TBX5)genes using polyethyleneimine (PEI)-based transfection is sufficient for transdifferentiation of adipose-derived stem cells (hADSCs) towards the cardiomyogenic lineage. PMID: 27553283
    19. Mef2c is highly expressed in the retina where it modulates photoreceptor-specific gene expression PMID: 28017720
    20. Study provides evidence that Mef2c cooperated with Sp1 to activate human AQP1 transcription by binding to its proximal promoter in human umbilical cord vein endothelial cells indicating that AQP1 is a direct target of Mef2c in regulating angiogenesis and vasculogenesis of endothelial cells. PMID: 26923194
    21. Data show that microRNA miR-27a was essential for the shift of mesenchymal stem cells (MSCs) from osteogenic differentiation to adipogenic differentiation in osteoporosis by targeting myocyte enhancer factor 2 c (Mef2c). PMID: 27337099
    22. New MEF2C mutation in MEF2C haploinsufficiency syndrome PMID: 27255693
    23. Long non-coding RNA uc.167 influences cell proliferation, apoptosis and differentiation of P19 cells by regulating Mef2c. PMID: 27268728
    24. We describe the prenatal identification of 5q14.3 duplication, including MEF2C, in a monochorionic twin pregnancy with corpus callosum anomalies, confirmed by autopsy. To the best of our knowledge, this cerebral finding has been observed for the first time in 5q14.3 duplication patients, possibly widening the neurological picture of this scarcely known syndrome. A pathogenetic role of MEF2C overexpression in brain develop PMID: 26864752
    25. The finding of a jugular pit in this patient facilitated the diagnosis, and he is, to our knowledge, the third case of jugular pit in association with 5q14.3 deletion incorporating the MEF2C locus. PMID: 26426104
    26. MiR-135b-5p and MiR-499a-3p Promote Cell Proliferation and Migration in Atherosclerosis by Directly Targeting MEF2C PMID: 26184978
    27. early B cell factor-1 (EBF1) was identified as a co-regulator of gene expression with MEF2C. PMID: 26900922
    28. Data show that high myocyte enhancer factor 2C (MEF2C) mRNA expression leads to overexpression of MEF2C protein, and these findings provide the rationale for therapeutic targeting of MEF2C transcriptional activation in acute myeloid leukemia. PMID: 26487643
    29. this is the first report of a Greek-Cypriot patient with a MEF2C-related phenotype highlighting the rich variability in phenotypic expression and the ethnic diversity associated with this condition. PMID: 25691421
    30. BCL2 inhibitors may be a therapeutic candidate in vivo for patients with ETP-ALL with high expression levels of MEF2C. PMID: 26172269
    31. MEF2C regulates the expression of G2/M checkpoint genes (14-3-3gamma, Gadd45b and p21) and the sub-cellular localization of CYCLIN B1. PMID: 25789873
    32. The overall effect of MEF2C in hepatocellular carcinoma progression regulation was dictated by its subcellular distribution. PMID: 25328135
    33. MEF2C/alpha-2-macroglobulin axis functions in endothelial cells as a negative feed-back mechanism that adapts sprouting activity to the oxygen concentration thus diminishing inappropriate and excess angiogenesis. PMID: 24988463
    34. MEF2C and MEF2D interact with the E3 ligase F-box protein SKP2, which mediates their subsequent degradation through the ubiquitin-proteasome system. PMID: 25733682
    35. Single nucleotide polymorphisms in ALDOB, MAP3K1, and MEF2C are associated with cataract. PMID: 25352737
    36. Alternative splicing of the alpha-exon of MEF2C regulates myogenesis. PMID: 25404735
    37. Combinations that resulted in higher protein levels of Mef2c enhanced reprogramming efficiency of cardiac myocytes. PMID: 25416133
    38. MEF2C binding in inflammatory pathways is associated with its role in bone density PMID: 24337390
    39. We identified MEF2C as a novel transcription factor that regulates Nampt expression through specific interaction sites at the promoter; its regulatory role was highly dependent on epigenetic modulations, especially under hypoxia conditions PMID: 23888946
    40. MEF2 regulatory network is disrupted in myotonic dystrophy cardiac tissue leading to altered expression of a large number of miRNA and mRNA targets. PMID: 24412363
    41. Results identify redox-mediated protein posttranslational modifications, including S-nitrosylation and sulfonation of a critical cysteine residue in MEF2, as an early event contributing to neuronal damage in Parkinson's disease induced by mitochondrial toxins. PMID: 24290359
    42. variants at MEF2C were associated with forearm bone mineral density (BMD), implicating this gene in the determination of BMD at forearm. [meta-analysis] PMID: 23572186
    43. One variant, rs2194025 on chromosome 5q14 near the myocyte enhancer factor 2C MEF2C gene, was associated with retinal arteriolar caliber in meta-analysis. PMID: 23776548
    44. MEF2C alpha- variants are significantly expressed during neuronal cell differentiation, indicating a putative role of these variants in development. PMID: 24008018
    45. Validated miR-223 targets MEF2C and PTBP2 were significantly upregulated in chronic myeloid leukemia samples. PMID: 23174904
    46. Mef2c regulates transcription of the extracellular matrix protein cartilage link protein 1 in the developing murine heart. PMID: 23468913
    47. A targeted search for MEF2C mutations could be applied to patients with a severe intellectual deficiency associated with absence of language and hypotonia, strabismus, and epilepsy. PMID: 23001426
    48. genetic association study in population of 1,012 Han women in China: Data suggest that an SNP in MEF2C (rs1366594) is associated with bone mineral density of lumbar spine and hip joint in aging women. PMID: 22798246
    49. SREBP-1 regulate muscle protein synthesis through the downregulation of the expression of MYOD1, MYOG and MEF2C factors. PMID: 23226416
    50. Mutations in MEF2C are probably a very rare cause of Rett syndrome. PMID: 22449245

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  • 相关疾病：
    Mental retardation, autosomal dominant 20 (MRD20)
  • 亚细胞定位：
    Nucleus. Cytoplasm, sarcoplasm.
  • 蛋白家族：
    MEF2 family
  • 组织特异性：
    Expressed in brain and skeletal muscle.
  • 数据库链接：

    HGNC: 6996

    OMIM: 600662

    KEGG: hsa:4208

    UniGene: Hs.649965