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MESDC2 Antibody

  • 货号：
    CSB-PA013708GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q14696
  • 基因名：
    MESD
  • 别名：
    BOCA antibody; KIAA0081 antibody; LDLR chaperone MESD antibody; MESD antibody; MESD_HUMAN antibody; MESDC 2 antibody; mesdc2 antibody; Mesoderm development candidate 2 antibody; Mesoderm development protein antibody; Renal carcinoma antigen NY REN 61 antibody; Renal carcinoma antigen NY-REN-61 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human MESDC2
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Chaperone specifically assisting the folding of beta-propeller/EGF modules within the family of low-density lipoprotein receptors (LDLRs). Acts as a modulator of the Wnt pathway through chaperoning the coreceptors of the canonical Wnt pathway, LRP5 and LRP6, to the plasma membrane. Essential for specification of embryonic polarity and mesoderm induction. Plays an essential role in neuromuscular junction (NMJ) formation by promoting cell-surface expression of LRP4. May regulate phagocytosis of apoptotic retinal pigment epithelium (RPE) cells.
  • 基因功能参考文献：
    1. Mesd C-terminal region constitutes the major LRP5/6-binding domain, and that Mesd protein and its C-terminal region peptide have a potential therapeutic value in cancer PMID: 23469146
    2. Results indicate that Mesd is a universal inhibitor of Wnt/LRP signaling on the cell surface. PMID: 21907199
    3. Results provide evidence that MESD functions as a general LRP chaperone and suggest that the Mesd phenotype results from both signaling and endocytic defects resulting from misfolding of multiple LRP receptors. PMID: 21337463
    4. Two structural and functional domains of MESD required for proper folding and trafficking of LRP5/LRP6. PMID: 21397183
    5. as a result of (12;15)(q13;q25)translocation, the SUMO/Sentrin-specific protease 1 gene (SENP1) on chromosome 12 and the embryonic polarity-related mesoderm development gene (MESDC2) on chromosome 15 are disrupted and fused PMID: 15917269
    6. Mesd and LRP6 modulate Wnt signaling. PMID: 16989816

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  • 亚细胞定位：
    Endoplasmic reticulum.
  • 蛋白家族：
    MESD family
  • 数据库链接：

    HGNC: 13520

    OMIM: 607783

    KEGG: hsa:23184

    STRING: 9606.ENSP00000261758

    UniGene: Hs.578450