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MESP2 Antibody

  • 货号：
    CSB-PA613150ESR1HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) MESP2 Polyclonal antibody
  • Uniprot No.：
    Q0VG99
  • 基因名：
    MESP2
  • 别名：
    Basic helix loop helix protein MESP 2 antibody; Basic helix loop helix protein MESP2 antibody; BHLH protein MesP2 antibody; bHLHc6 antibody; Class C basic helix-loop-helix protein 6 antibody; Hypothetical class II basic helix loop helix protein MESP 2 antibody; Hypothetical class II basic helix loop helix protein MESP2 antibody; Mesoderm posterior 2 antibody; mesoderm posterior 2 homolog (mouse) antibody; Mesoderm posterior 2 homolog antibody; Mesoderm posterior protein 2 antibody; Mesp 2 antibody; MESP2 antibody; MESP2_HUMAN antibody; SCDO 2 antibody; SCDO2 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Mesoderm posterior protein 2 protein (218-397AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Transcription factor with important role in somitogenesis. Defines the rostrocaudal patterning of the somite by participating in distinct Notch pathways. Regulates also the FGF signaling pathway. Specifies the rostral half of the somites. Generates rostro-caudal polarity of somites by down-regulating in the presumptive rostral domain DLL1, a Notch ligand. Participates in the segment border formation by activating in the anterior presomitic mesoderm LFNG, a negative regulator of DLL1-Notch signaling. Acts as a strong suppressor of Notch activity. Together with MESP1 is involved in the epithelialization of somitic mesoderm and in the development of cardiac mesoderm.
  • 基因功能参考文献：
    1. Mutated MESP2 causes spondylocostal dysostosis PMID: 15122512
    2. Mesp1 is down-regulated in the later stages of development by increasing levels of Mesp2 in the wild-type embryo. PMID: 16996494
    3. findings suggest a founder-effect mutation in the MESP2 gene as a major cause of the classical Puerto Rican form of spondylothoracic dysostosis/Jarcho-Levin syndrome PMID: 18485326
  • 相关疾病：
    Spondylocostal dysostosis 2, autosomal recessive (SCDO2)
  • 亚细胞定位：
    Nucleus.
  • 数据库链接：

    HGNC: 29659

    OMIM: 605195

    KEGG: hsa:145873

    STRING: 9606.ENSP00000342392

    UniGene: Hs.37311