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  4. MIER1 Antibody

MIER1 Antibody

  • 中文名称：
    MIER1兔多克隆抗体
  • 货号：
    CSB-PA013823GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q8N108
  • 基因名：
    MIER1
  • 别名：
    MIER1 antibody; KIAA1610 antibody; Mesoderm induction early response protein 1 antibody; Early response 1 antibody; Er1 antibody; Mi-er1 antibody; hMi-er1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human MIER1
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Transcriptional repressor regulating the expression of a number of genes including SP1 target genes. Probably functions through recruitment of HDAC1 a histone deacetylase involved in chromatin silencing.
  • 基因功能参考文献：
    1. Biochemical analysis of the BAHD1-associated multiprotein complex identifies MIER proteins as novel partners of BAHD1 and suggests that BAHD1-MIER interaction forms a hub for histone deacetylases and methyltransferases PMID: 26938916
    2. Insulin and IGF-1 alter the subcellular localization of MIER1alpha in breast carcinoma cells. PMID: 26281834
    3. nuclear targeting of MIER1alpha requires an intact ELM2 domain and is dependent on interaction with HDAC1/2 PMID: 24376786
    4. the first immunohistochemical study of the MIER1alpha protein expression pattern in human tissues, is reported. PMID: 23277184
    5. Differential splicing alters subcellular localization of the alpha but not beta isoform of the MIER1 transcriptional regulator in breast cancer cells PMID: 22384264
    6. Results demonstrate that alternate use of a facultative intron regulates the subcellular localization of hMI-ER1 proteins and this may have important implications for hMI-ER1 function. PMID: 12242014
    7. we investigated the role of hMI-ER1alpha and hMI-ER1beta in the regulation of transcription.We demonstrate that this repressor activity is due to interaction and recruitment of a trichostatin A-sensitive histone deacetylase 1 (HDAC1). PMID: 12482978
    8. the association of hMI-ER1 with Sp1 represents a novel mechanism for the negative regulation of Sp1 target promoters PMID: 15117948
    9. Loss of nuclear MI-ER1 alpha might contribute to the development of invasive breast carcinoma PMID: 18665173

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  • 亚细胞定位：
    [Isoform 1]: Nucleus.; [Isoform 2]: Nucleus.; [Isoform 3]: Nucleus.; [Isoform 4]: Cytoplasm.; [Isoform 5]: Cytoplasm.; [Isoform 6]: Cytoplasm.
  • 组织特异性：
    Ubiquitously expressed, but at very low levels. However, consistent level of expression are observed in heart, testis, thyroid, ovary and adrenal gland. Transcripts are up-regulated in breast carcinoma cell lines and tumor.
  • 数据库链接：

    HGNC: 29657

    KEGG: hsa:57708

    STRING: 9606.ENSP00000383820

    UniGene: Hs.605432