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MIP1 Antibody

  • 货号：
    CSB-PA322240XA01SVG
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in Recombinant protein
      All lanes: MIP1 antibody at 1:2000
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 60 kDa
      Observed band size: 60 kDa
  • 其他：

产品详情

  • Uniprot No.：
    P15801
  • 基因名：
    MIP1
  • 别名：
    DNA polymerase gamma (EC 2.7.7.7) (Mitochondrial DNA polymerase catalytic subunit) MIP1 YOR330C
  • 反应种属：
    Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
  • 免疫原：
    Recombinant Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) MIP1 protein (1-250aa )
  • 免疫原种属：
    Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Protein G
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Involved in the replication of mitochondrial DNA.
  • 基因功能参考文献：
    1. Yeast Mip1, the mitochondrial DNA polymerase gamma, harbors a conserved C-terminal extension required for maintenance of mitochondrial DNA in vivo. PMID: 16491467
    2. Our study also further confirms the utility of yeast Mip1p as a tool for studying human DNA polymerase (pol gamma)variants. PMID: 26077851
    3. Disrupting exonuclease activity of mutant variants was not associated with increased spontaneous mutagenesis compared with exonuclease-proficient alleles, suggesting that most or all of the mtDNA was replicated by wild type Mip1. PMID: 25340760
    4. disruption of Mip1 exonuclease activity increases mtDNA deletions 160-fold. PMID: 23589460
    5. Point mutations in the 3'-5' exonuclease domain of Mip1 result in severe impairment of the polymerase function and DNA binding. PMID: 20601675
    6. mip1 containing mutations associated with mitochondrial disease causes mutagenesis and depletion of mtDNA in Saccharomyces cerevisiae. PMID: 20185557
    7. Mip1p contains a single nucleotide polymorphism changing the strictly conserved threonine 661 to alanine. This substitution is responsible for the increased rate of mitochondrial DNA point mutations and deletions in these strains. PMID: 17720904
    8. The yeast mitochondrial DNA (mtDNA) replicase Mip1 has been used as a model to generate five mutations equivalent to POLG mutations associated with a broad spectrum of diseases in human. PMID: 17980715

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  • 亚细胞定位：
    Mitochondrion.
  • 蛋白家族：
    DNA polymerase type-A family
  • 数据库链接：

    KEGG: sce:YOR330C

    STRING: 4932.YOR330C