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MLH3 Antibody

  • 货号：
    CSB-PA262280
  • 规格：
    ￥2024
  • 图片：
    • Western blot analysis of extracts from K562 cells and HT-29 cells, using MLH3 antibody.
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) MLH3 Polyclonal antibody
  • Uniprot No.：
    Q9UHC1
  • 基因名：
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthesized peptide derived from internal of Human MLH3.
  • 免疫原种属：
    Homo sapiens (Human)
  • 克隆类型：
    Polyclonal
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:3000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Probably involved in the repair of mismatches in DNA.
  • 基因功能参考文献：
    1. The effects of chronic smoking on oral mucosa led to the methylation of genes MRE11A PMS2, XRCC1 and MLH3, but resulted in a reduction of gene expression of MRE11A and PMS2, which showed >/=50% methylation. These results provide evidence that smoking cause methylation and reduced expression of repair genes. PMID: 29775861
    2. MLH3 germline variants are associated with colon cancer patients belonging to families with Lynch syndrome-associated brain tumors. PMID: 27401157
    3. A polymorphism within the MLH3 gene is associated with oligozoospermia in Caucasian men of a certain area. PMID: 26520453
    4. MutL homolog 3 (MLH3) promoter methylation was observed in 61% of oligoastrocytoma and 27% of astrocytoma. PMID: 26303387
    5. Results indicate that CT(844)-CC(942) was associated with a high risk of cervical carcinoma and cervical intraepithelial neoplasia, and the CC(844)-CT(942) decreased the risk. PMID: 24759751
    6. The experiments show recruitment and persistence of MutLgamma-heterodimers at UVA-induced DNA lesions. PMID: 23696135
    7. the MutSbeta-MutLalpha interaction is mediated in part by residues ((L/I)SRFF) embedded within the MSH3 PCNA-binding motif PMID: 20154325
    8. hMLH3 mRNA is present at low levels in numerous tissues but high levels in testis. hMLH3 functions in meiosis as well as hMSH2-hMSH3 repair processes & has little if any role in Hereditary Non-Polyposis Colorectal Cancer (HNPCC). PMID: 19483466
    9. There is an association of polymorphism C85T in MSH5 or C2531T in MLH3 with male infertility, specifically azoospermia or severe oligozoospermia, and interaction between these MSH5 and MLH3 polymorphisms increased the risk of developing male infertility PMID: 19808033
    10. Little evidence for involvement of MLH3 in colorectal cancer predisposition. PMID: 12800209
    11. at pachynema, when chromosomes are fully paired, we find significant heterogeneity in the localization of the MutL homologs, MLH1 and MLH3, among human oocyte populations PMID: 15558497
    12. The identification of inherited missense variants, somatic missense mutations (present in 3 of 57 tumors), and LOH in the tumor from a patient with a germ line missense change suggest a role for MLH3 in endometrial tumorigenesis. PMID: 16885347
    13. Mutations of Mlh3 may work together with other genes in an accumulated manner and result in an increased risk of esophageal tumor PMID: 16981255
    14. in absence of hPMS2, hMLH3 (hMutLgamma) is located in the nucleus, suggesting a conditional activity in MMR and supporting its role as a low-risk gene in hereditary non-polyposis colorectal cancer PMID: 17203173
    15. Two simultaneous hMLH3 variants might predispose to spermatogenic arrest. PMID: 17482610
    16. results suggest that the endonuclease activity of MutLalpha is important not only in MMR-dependent mutation avoidance but also for recombination and damage response functions PMID: 17567544
    17. MLH3 and EXO1 alterations in familial colorectal cancer patients not fulfilling Amsterdam criteria. PMID: 17656264
    18. To assess the significance of the inherited sequence variations in MLH3, we functionally characterized seven missense mutations PMID: 18521850
    19. Mlh3 nullizygosity significantly increased Apc frameshift mutations and tumor multiplicity. PMID: 18551179
    20. the different biochemical assays yielded no evidence that the eight MLH3 unclassified variants (missense mutations) tested are the cause of hereditary colorectal cancer, including Lynch syndrome PMID: 19156873

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  • 相关疾病：
    Hereditary non-polyposis colorectal cancer 7 (HNPCC7); Colorectal cancer (CRC)
  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    DNA mismatch repair MutL/HexB family
  • 组织特异性：
    Ubiquitous.
  • 数据库链接：

    HGNC: 7128

    OMIM: 114500

    KEGG: hsa:27030

    STRING: 9606.ENSP00000348020

    UniGene: Hs.436650