Your Good Partner in Biology Research

  1. Home
  2. 抗体
  3. 多克隆抗体
  4. MLK4 Antibody

MLK4 Antibody

  • 货号：
    CSB-PA003249
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of HT29 cells using MLK4 Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    Q5TCX8
  • 基因名：
    MAP3K21
  • 别名：
    dJ862P8.3 antibody; KIAA1804 antibody; M3KL4_HUMAN antibody; Mitogen activated protein kinase kinase kinase antibody; Mitogen-activated protein kinase kinase kinase MLK4 antibody; Mixed lineage kinase 4 antibody; MLK 4 antibody; Mlk4 antibody; RP5 862P8.2 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human MLK4.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:20000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Negative regulator of TLR4 signaling. Does not activate JNK1/MAPK8 pathway, p38/MAPK14, nor ERK2/MAPK1 pathways.
  • 基因功能参考文献：
    1. These results suggest that in the early response to stressful stimuli, MLK4beta-MLK3 binding is important for regulating MLK3 activity and MAPK signalling, and after prolonged periods of stress exposure, MLK4beta and MLK3 proteins decline via CHIP-dependent degradation. PMID: 28757353
    2. results uncover MLK4 as an upstream regulator of NF-kappaB signaling and a potential molecular target for the MES subtype of glioblastomas PMID: 26859459
    3. In establishing the role of MLK4 in intracellular signaling, we show it directly phosphorylates MEK1 (MAP2K1) and that MEK/ERK (MAPK1) signaling is impaired in MLK4 knockout cells PMID: 23319808
    4. MLK4 is a negative regulator of TLR4 signaling. PMID: 21602844
  • 蛋白家族：
    Protein kinase superfamily, STE Ser/Thr protein kinase family, MAP kinase kinase kinase subfamily
  • 数据库链接：

    HGNC: 29798

    OMIM: 614793

    KEGG: hsa:84451

    STRING: 9606.ENSP00000355583

    UniGene: Hs.547779