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  4. MMP25 Antibody

MMP25 Antibody

  • 货号：
    CSB-PA926432
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using CSB-PA926432(MMP25 Antibody) at dilution 1/80, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA926432(MMP25 Antibody) at dilution 1/80, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • Gel: 10+12%SDS-PAGE, Lysate: 40 μg, Lane: 823 cells, Primary antibody: CSB-PA926432(MMP25 Antibody) at dilution 1/1300, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes
  • 其他：

产品详情

  • Uniprot No.：
    Q9NPA2
  • 基因名：
    MMP25
  • 别名：
    Leukolysin antibody; matrix metallopeptidase 25 antibody; matrix metallopeptidase like 1 antibody; matrix metalloproteinase 20 antibody; Matrix Metalloproteinase 25 antibody; Matrix metalloproteinase 25 precursor antibody; Matrix metalloproteinase-25 antibody; Membrane type 6 Matrix Metalloproteinase antibody; Membrane type Matrix Metalloproteinase 6 antibody; Membrane-type matrix metalloproteinase 6 antibody; Membrane-type-6 matrix metalloproteinase antibody; MMP 25 antibody; MMP-25 antibody; MMP20 antibody; MMP20A antibody; MMP25 antibody; MMP25_HUMAN antibody; MMPL1 antibody; MT MMP 6 antibody; MT-MMP 6 antibody; MT6 MMP antibody; MT6-MMP antibody; MT6MMP antibody; MTMMP6 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthetic peptide of Human MMP25
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    WB 1:500-1:2000
    IHC 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    May activate progelatinase A.
  • 基因功能参考文献：
    1. In absolute mRNA levels, significant differences were found in expression of MMP2, MMP24, and MMP25 in gastric carcinoma compared with superficial gastritis. PMID: 24669030
    2. IL-2-upregulated MT6 cell-surface expression correlates with CD16 downmodulation. MT6, sequestered in intracellular compartments in unstimulated NK cells, translocates to the effector-target cell interface of CD16-mediated immunological synapses. PMID: 23851692
    3. MT6-MMP regulates neutrophil and monocyte chemotaxis and by generating "eat-me" signals upon vimentin cleavage potentially increases phagocytic removal of neutrophils to resolve inflammation. PMID: 22367194
    4. MT6-MMP is present in the membrane, granules and nuclear/endoplasmic reticulum/Golgi fractions of PMNs where it is displayed as a disulfide-linked homodimer of 120 kDa PMID: 20501611
    5. individuals with history of chronic airways inflammation (asthma and COPD) serum leukolysin may be a metabolic marker associated with chronic atopy-associated respiratory inflammation. PMID: 20337648
    6. Biochemical characterization of the cellular glycosylphosphatidylinositol-linked membrane type-6 matrix metalloproteinase. PMID: 20308072
    7. MMP25 is regulated by clusterin in vivo PMID: 12860995
    8. MT6-MMP may play a role in colon cancer and exhibit unique biochemical and structural properties that may regulate proteolytic function at the cell surface. PMID: 17513868
    9. the stem region of MT6-MMP is the dimerization interface, an event whose outcome imparts protease stability to the protein PMID: 18936094
    10. MMP-25 plays an important role in multiple sclerosis pathology PMID: 19726693

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  • 亚细胞定位：
    Cell membrane; Lipid-anchor, GPI-anchor; Extracellular side. Secreted, extracellular space, extracellular matrix.
  • 蛋白家族：
    Peptidase M10A family
  • 组织特异性：
    Expressed predominantly in leukocytes, lung and spleen. Expressed also in colon carcinoma, astrocytoma and glioblastomas.
  • 数据库链接：

    HGNC: 14246

    OMIM: 608482

    KEGG: hsa:64386

    STRING: 9606.ENSP00000337816

    UniGene: Hs.654979