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MN1 Antibody

  • 货号：
    CSB-PA003259
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of COLO205 cells using MN1 Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    Q10571
  • 基因名：
    MN1
  • 别名：
    AA003644 antibody; AA009236 antibody; dJ353E16.2 antibody; Meningioma (disrupted in balanced translocation) 1 antibody; Meningioma (translocation balanced) antibody; Meningioma 1 antibody; meningioma chromosome region 1 antibody; MGCR antibody; MGCR1 antibody; MGCR1-PEN antibody; MN1 antibody; MN1_HUMAN antibody; Probable tumor suppressor protein MN1 antibody; RGD1565571 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human MN1.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:40000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Transcriptional activator which specifically regulates expression of TBX22 in the posterior region of the developing palate. Required during later stages of palate development for growth and medial fusion of the palatal shelves. Promotes maturation and normal function of calvarial osteoblasts, including expression of the osteoclastogenic cytokine TNFSF11/RANKL. Necessary for normal development of the membranous bones of the skull. May play a role in tumor suppression (Probable).
  • 基因功能参考文献：
    1. Study suggests a role for DNMT3B in leukemogenesis in inv(16) acute myeloid leukemia, through MN1 methylation regulation. PMID: 28892045
    2. The data obtained show that normal cells consistently express low levels of MN1 transcript. In contrast, high levels of MN1 expression are present in 47% of patients with normal karyotype and in all cases with inv(16). PMID: 27765915
    3. Patients with t(12;22)/MN1-EVT6 oncogene, are frequently associated with myeloid neoplasms, poor response to chemotherapy, and inferior outcome. PMID: 29273914
    4. MN1 gene expression in acute myeloid leukemia. PMID: 27983532
    5. MN1 deletion is associated with Craniofacial Abnormalities. PMID: 26545049
    6. Chromosome 22q12.1 microdeletions involving the MN1 gene confirm it as a candidate gene for cleft palate. PMID: 25944382
    7. genotype-phenotype correlation among our patients and those previously reported with overlapping 22q12 deletions, we identified a 560 kb critical region containing the MN1 gene that is implicated in human cleft palate formation PMID: 25810350
    8. these results suggest that deregulated MN1 expression contributes to the pathogenesis of pediatric B-ALL. PMID: 26111797
    9. identified potential driver mutations in NF2 (neurofibromatosis type 2) and MN1 (meningioma 1). PMID: 25549701
    10. cotransduction of an activated HOX gene (NUP98HOXD13) with MN1 induces a serially transplantable acute myeloid leukemia (AML). PMID: 25339361
    11. MN1 overexpression independently predicts bad clinical outcome in CN-AML patients PMID: 23394438
    12. High MN1 expression confers worse prognosis in Chinese adult patients with de novo acute myeloid leukemia. PMID: 23515710
    13. Overexpression of MN1 confers resistance to chemotherapy, accelerates leukemia onset, and suppresses p53 and Bim induction PMID: 22905229
    14. A high MEBE (MN1,ERG, BAALC, EVI1) expression score is an unfavorable prognostic marker in Myelodysplastic syndrome and is associated with an increased risk for progression to Acute myeloid leukemia. PMID: 22488406
    15. analysis of genetic variants hints at the contribution of TGFB3 and MN1 in the aetiology of submucous cleft palate PMID: 22409215
    16. low MN1 expression confers better prognosis in older CN-AML patients and may refine the European LeukemiaNet classification. Biologic features associated with MN1 expression may help identify new treatment targets. PMID: 21828125
    17. MN1-ETV6 fusion gene arising from Myelodysplastic Syndrome with 5q trisomy is associated with acute myeloid leukemia. PMID: 21600651
    18. high MN1 levels are important for the growth of leukemic cells, and that increased MN1 expression can synergize with MLL-ENL and probably other transforming fusion genes in leukemia induction. PMID: 20072157
    19. MN1 is a 1,25-(OH)2D3-induced vitamin D receptor coactivator that also may have critical roles in modulating osteoblast proliferation. PMID: 15890672
    20. MN1-translocation-ETS-leukemia exerts its nonlineage-specific leukemogenic effects by promoting the growth of primitive progenitors and blocking their differentiation PMID: 16081688
    21. leukemogenic effect of MN1-ets variant gene 6 L in our knock-in mice is pleiotropic, and the type of secondary mutation determines disease outcome PMID: 16105979
    22. Up-regulates Insulin-Like Growth Factor Binding Protein 5 at a specific promoter consensus sequence. PMID: 17242174
    23. MN1 is a unique oncogene in hematopoiesis that both promotes proliferation/self-renewal and blocks differentiation, and may become useful as a predictive marker in AML treatment. PMID: 17494859
    24. MN1 overexpression is associated with the development of inv(16) acute myeloid leukemia PMID: 17525718
    25. role of MN1 in myeloid leukemia [review] PMID: 17698380
    26. MN1 and MN1-TEL interfere with the ATRA pathway and this might explain the differentiation block in leukemias in which these genes are involved. PMID: 18632758
    27. Data demonstrate that MN1 overexpression correlates with progression from MDS to sAML and therefore might be involved in the pathogenesis of sAML PMID: 19391034
    28. MN1 expression independently predicts outcome in cytogenetically normal acute myeloid leukemia PMID: 19451432
    29. Down-regulation of CEBPA activity contributes to MN1-modulated proliferation and impaired myeloid differentiation of hematopoietic cells. PMID: 19561324

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  • 相关疾病：
    A chromosomal aberration involving MN1 may be a cause of acute myeloid leukemia (AML). Translocation t(12;22)(p13;q11) with ETV6.
  • 亚细胞定位：
    Nucleus.
  • 组织特异性：
    Widely expressed in fetal and adult tissues. Highest expression is observed in fetal brain and skeletal muscle, and adult skeletal muscle.
  • 数据库链接：

    HGNC: 7180

    OMIM: 156100

    KEGG: hsa:4330

    STRING: 9606.ENSP00000304956

    UniGene: Hs.268515