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MOCS1 Antibody

  • 货号：
    CSB-PA878934ESR2HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: MOCS1 antibody at 2.24 μg/ml + Jurkat whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 71, 44, 41, 32, 69, 59 kDa
      Observed band size: 71, 55 kDa
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) MOCS1 Polyclonal antibody
  • Uniprot No.：
    Q9NZB8
  • 基因名：
    MOCS1
  • 别名：
    Cell migration-inducing gene 11 protein antibody; MIG11 antibody; Migration inducing gene 11 protein antibody; MOCOD antibody; MOCODA antibody; Mocs1 antibody; MOCS1_HUMAN antibody; Molybdenum cofactor biosynthesis protein 1 antibody; Molybdenum cofactor biosynthesis protein A antibody; Molybdenum cofactor biosynthesis protein C antibody; Molybdenum cofactor synthesis 1 antibody; Molybdenum cofactor synthesis-step 1 protein A-B antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Molybdenum cofactor biosynthesis protein 1 protein (90-360AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:1000-1:5000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Isoform MOCS1A and isoform MOCS1B probably form a complex that catalyzes the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP). MOCS1A catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate and MOCS1B catalyzes the subsequent conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cPMP.
  • 基因功能参考文献：
    1. Case Report: in a mild case of molybdenum cofactor deficiency detected two proteins: a truncated MOCS1AB protein and a 22.4 kDa protein representing MOCS1B, demonstrating an unusual mechanism of translation re-initiation in the MOCS1 transcript, which results in trace amounts of functional MOCS1B protein being sufficient to partially protect the patient from the most severe symptoms. PMID: 29368224
    2. Review: A total of 32 different disease-causing mutations, including several common to more than one family, have been identified in molybdenum cofactor-deficient patients and their relatives PMID: 12754701
    3. MOCS1A is an oxygen-sensitive iron-sulfur protein involved in human molybdenum cofactor biosynthesis PMID: 15180982
    4. genetic and protein structural analysis of MOCS1 in molybdenum cofactor deficiency [case report] PMID: 17065069
  • 相关疾病：
    Molybdenum cofactor deficiency, complementation group A (MOCODA)
  • 蛋白家族：
    MoaC family; Radical SAM superfamily, MoaA family
  • 组织特异性：
    Isoform MOCS1A and isoform 2 are widely expressed.
  • 数据库链接：

    HGNC: 7190

    OMIM: 252150

    KEGG: hsa:4337

    STRING: 9606.ENSP00000362282

    UniGene: Hs.357128