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MOV10L1 Antibody

  • 货号：
    CSB-PA871604LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in: Hela whole cell lysate, PC-3 whole cell lysate
      All lanes: MOV10L1 antibody at 6.5µg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 136, 38, 14, 130, 131 kDa
      Observed band size: 136 kDa
    • IHC image of CSB-PA871604LA01HU diluted at 1:400 and staining in paraffin-embedded human breast cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
    • IHC image of CSB-PA871604LA01HU diluted at 1:400 and staining in paraffin-embedded human liver cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
    • Immunofluorescence staining of HepG2 cells with CSB-PA871604LA01HU at 1:133, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) MOV10L1 Polyclonal antibody
  • Uniprot No.：
    Q9BXT6
  • 基因名：
    MOV10L1
  • 别名：
    Cardiac helicase activated by MEF2 protein antibody; Cardiac specific RNA helicase antibody; CHAMP antibody; Csm antibody; M10L1_HUMAN antibody; Moloney leukemia virus 10 like protein 1 antibody; Moloney leukemia virus 10-like protein 1 antibody; MOV10 like 1 antibody; MOV10 like protein 1 antibody; MOV10-like protein 1 antibody; MOV10L1 antibody; Mov10l1; Moloney leukemia virus 10 like 1; homolog (mouse) antibody; Putative helicase Mov10l1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human RNA helicase Mov10l1 protein (336-425AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，MOV10L1 Antibody (CSB-PA871604LA01HU)，的标记方式是Non-conjugated。对于MOV10L1 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA871604LB01HU MOV10L1 Antibody, HRP conjugated ELISA
    FITC CSB-PA871604LC01HU MOV10L1 Antibody, FITC conjugated
    Biotin CSB-PA871604LD01HU MOV10L1 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:200-1:500
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    ATP-dependent RNA helicase required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Involved in the primary piRNA metabolic process. Specifically binds to piRNA precursors and promotes the generation of intermediate piRNA processing fragments that are subsequently loaded to Piwi proteins. Acts via its ATP-dependent RNA helicase activity: displays 5'-3' RNA unwinding activity and probably mediates unwinding and funneling of single-stranded piRNA precursor transcripts to the endonuclease that catalyzes the first cleavage step of piRNA processing to generate piRNA intermediate fragments that are subsequently loaded to Piwi proteins.
  • 基因功能参考文献：
    1. Our results suggest that MOV10L1 gene polymorphisms in the studied infertile males with complete maturation arrest are linked to infertility. PMID: 24817005
  • 亚细胞定位：
    Cytoplasm.
  • 蛋白家族：
    DNA2/NAM7 helicase family, SDE3 subfamily
  • 组织特异性：
    [Isoform 1]: Specifically expressed in testis.
  • 数据库链接：

    HGNC: 7201

    OMIM: 605794

    KEGG: hsa:54456

    STRING: 9606.ENSP00000262794

    UniGene: Hs.62880