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MPHOSPH8 Antibody

  • 货号：
    CSB-PA014752GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q99549
  • 基因名：
    MPHOSPH8
  • 别名：
    HSMPP8 antibody; M-phase phosphoprotein 8 antibody; M-phase phosphoprotein, mpp antibody; M-phase phosphoprotein, mpp8 antibody; MPHOSPH8 antibody; MPP8_HUMAN antibody; RP11-523H24.1 antibody; Twa3 antibody; Two hybrid-associated protein 3 with RanBPM antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human MPHOSPH8
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Heterochromatin component that specifically recognizes and binds methylated 'Lys-9' of histone H3 (H3K9me) and promotes recruitment of proteins that mediate epigenetic repression. Mediates recruitment of the HUSH complex to H3K9me3 sites: the HUSH complex is recruited to genomic loci rich in H3K9me3 and is required to maintain transcriptional silencing by promoting recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3, as well as MORC2. Binds H3K9me and promotes DNA methylation by recruiting DNMT3A to target CpG sites; these can be situated...显示更多
  • 基因功能参考文献：
    1. The study demonstrated that MPP8 was associated with non-small cell lung cancer cell proliferation through regulation of HOXA5. PMID: 29412790
    2. The haploid screen identified HUSH, an epigenetic heterochromatin repressor complex composed of three subunits, TASOR, MPP8 and Periphilin. (Review) PMID: 26853531
    3. findings demonstrate MPP8 and SIRT1 reciprocally regulate each other's function at multiple molecular layers through physical interaction; disruption of MPP8-SIRT1 interaction de-represses E cadherin expression and reduces cell motility and invasiveness suggesting this interplay plays critical role in MPP8- and SIRT1-mediated epithelial-mesenchymal transition PMID: 25870236
    4. this study identified the HUSH (human silencing hub) complex, comprising three poorly characterized proteins, TASOR, MPP8, and periphilin; this complex is absent from Drosophila but is conserved from fish to humans. PMID: 26022416
    5. Knockdown analysis of MPP8 in HeLa cells resulted in derepression of a set of genes that are normally expressed in spermatogonia, spermatids and mature sperm, thereby indicating a role for this molecule in silencing testis-related genes in somatic cells. PMID: 25660450
    6. interaction of HN with MPP8 may play a role in oncogenesis because MPP8 increases tumor cell motility and invasion PMID: 23532874
    7. these results indicate that the chromatin association of MPP8 is regulated by Cdk-dependent phosphorylation. PMID: 23416073
    8. These findings reveal the molecular mechanism of selective binding of human MPP8 chromodomain to methylated histone H3K9. PMID: 22022377
    9. We determined the crystal structure of MPP8 chromodomain in complex with H3K9me3 peptide. MPP8 interacts with at least six histone H3 residues from glutamine 5 to serine 10. PMID: 21419134
    10. MPP8 mediates E-cadherin gene silencing and promotes breast tumour cell motility and invasion. PMID: 20871592

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  • 亚细胞定位：
    Nucleus. Chromosome.
  • 数据库链接：

    HGNC: 29810

    OMIM: 611626

    KEGG: hsa:54737

    STRING: 9606.ENSP00000355388

    UniGene: Hs.269654