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MPP1 Antibody

  • 货号：
    CSB-PA014758LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human small intestine tissue using CSB-PA014758LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA014758LA01HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) MPP1 Polyclonal antibody
  • Uniprot No.：
    Q00013
  • 基因名：
    MPP1
  • 别名：
    55 kDa erythrocyte membrane protein antibody; AAG 12 antibody; AAG12 antibody; Aging associated gene 12 antibody; DXS552 antibody; DXS552E antibody; EM55_HUMAN antibody; EMP 55 antibody; EMP55 antibody; Erythrocyte membrane protein p55 antibody; Membrane protein antibody; Membrane protein palmitoylated 1 55kDa antibody; Membrane protein palmitoylated 1 antibody; Membrane protein; palmitoylated 1; 55kDa antibody; Migration related gene 1 antibody; MPP 1 antibody; MPP1 antibody; MRG 1 antibody; MRG1 antibody; OTTHUMP00000026054 antibody; OTTHUMP00000196176 antibody; p55 antibody; palmitoylated 1 antibody; Palmitoylated erythrocyte membrane protein antibody; Palmitoylated membrane protein 1 antibody; PEMP antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human 55 kDa erythrocyte membrane protein (123-252AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，MPP1 Antibody (CSB-PA014758LA01HU)，的标记方式是Non-conjugated。对于MPP1 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA014758LB01HU MPP1 Antibody, HRP conjugated ELISA
    FITC CSB-PA014758LC01HU MPP1 Antibody, FITC conjugated
    Biotin CSB-PA014758LD01HU MPP1 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Essential regulator of neutrophil polarity. Regulates neutrophil polarization by regulating AKT1 phosphorylation through a mechanism that is independent of PIK3CG activity.
  • 基因功能参考文献：
    1. Data suggest that targeting the ATP binding cassette subfamily C member 4 (ABCC4)-membrane palmitoylated protein 1 (MPP1) protein complex can lead to new therapies to improve treatment outcome of acute myeloid leukemia (AML). PMID: 29146910
    2. A new perspective on the role of MPP1 in erythroid cells suggests that direct MPP1-flotillins interactions could be the major driving-force behind the formation of raft domains in red blood cells. PMID: 28865798
    3. conclusion, the data demonstrates that MPP1 interacts with lipid mixtures in two different model membrane systems. PMID: 28653654
    4. Studies indicate that palmitoylated erythrocyte membrane protein p55 (MPP1) and its palmitoylation play a crucial role in lateral membrane organization in erythroid cells. PMID: 25408337
    5. MPP1 knockdown significantly affects the activation of MAP-kinase signaling. PMID: 23507198
    6. MPP1 gene expression is decreased in both classic and follicular variants of papillary thyroid carcinoma. PMID: 21509594
    7. Results show the NMR-derived structure of the human erythroid p55 PDZ domain and propose a possible interaction mode with the C-terminus of glycophorin C. PMID: 16741958
    8. MPP1 links the Usher protein network and the Crumbs protein complex in the retina PMID: 17584769
    9. p55 binds to two distinct sites within the FERM domain, and the alternatively spliced exon 5 is necessary for the membrane targeting of protein 4.1R in epithelial cells. PMID: 18952129
    10. p55-NF2 protein interaction may play a functional role in the regulation of apico-basal polarity and tumor suppression pathways in non-erythroid cells. PMID: 19144871

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  • 亚细胞定位：
    Cell membrane; Lipid-anchor. Cell projection, stereocilium.
  • 蛋白家族：
    MAGUK family
  • 组织特异性：
    Ubiquitous.
  • 数据库链接：

    HGNC: 7219

    OMIM: 305360

    KEGG: hsa:4354

    STRING: 9606.ENSP00000358547

    UniGene: Hs.496984